貴(gui)陽(yang)市(shi)第(di)二十一中(zhong)(zhong)(zhong)學(xue)(xue)(xue)于1905年(nian)(nian)始建(jian)，稱(cheng)“官(guan)立學(xue)(xue)(xue)堂”，后曾以“省立模范學(xue)(xue)(xue)校(xiao)(xiao)”、“省立貴(gui)陽(yang)一中(zhong)(zhong)(zhong)”、“貴(gui)陽(yang)中(zhong)(zhong)(zhong)學(xue)(xue)(xue)”命名。解放后更(geng)(geng)名為(wei)(wei)貴(gui)陽(yang)二中(zhong)(zhong)(zhong)，1963年(nian)(nian)學(xue)(xue)(xue)校(xiao)(xiao)更(geng)(geng)名為(wei)(wei)貴(gui)陽(yang)市(shi)第(di)二十一中(zhong)(zhong)(zhong)學(xue)(xue)(xue)。學(xue)(xue)(xue)校(xiao)(xiao)地處貴(gui)陽(yang)市(shi)中(zhong)(zhong)(zhong)心(xin)區(qu)，坐(zuo)落在護(hu)國(guo)路(lu)上(shang)，南鄰市(shi)內交通(tong)樞紐萬東(dong)大道，北接小(xiao)十字繁(fan)華商業(ye)區(qu)，西(xi)靠市(shi)中(zhong)(zhong)(zhong)心(xin)商業(ye)主干(gan)道富水南路(lu)，學(xue)(xue)(xue)校(xiao)(xiao)面積12000m2，有專業(ye)技術人(ren)(ren)(ren)員(yuan)78人(ren)(ren)(ren)，其(qi)中(zhong)(zhong)(zhong)高(gao)級職(zhi)稱(cheng)21人(ren)(ren)(ren)，中(zhong)(zhong)(zhong)級職(zhi)稱(cheng)32人(ren)(ren)(ren)，初級職(zhi)稱(cheng)25人(ren)(ren)(ren)。學(xue)(xue)(xue)歷(li)達標100%，其(qi)中(zhong)(zhong)(zhong)本科學(xue)(xue)(xue)歷(li)63人(ren)(ren)(ren)，專科學(xue)(xue)(xue)歷(li)15人(ren)(ren)(ren)。截止2019年(nian)(nian)有學(xue)(xue)(xue)生986人(ren)(ren)(ren)，其(qi)中(zhong)(zhong)(zhong)七年(nian)(nian)級410人(ren)(ren)(ren)，八年(nian)(nian)級320人(ren)(ren)(ren)，九年(nian)(nian)級256人(ren)(ren)(ren)。
學校以(yi)人(ren)為本，重抓素質(zhi)教育(yu)，努力培養學生(sheng)的(de)實(shi)踐(jian)能(neng)力和創新能(neng)力，學校的(de)校訓是“教人(ren)求(qiu)真，學做真人(ren)”；學校的(de)辦學方向(xiang)是“以(yi)質(zhi)量求(qiu)生(sheng)存，以(yi)特(te)色促發展，將(jiang)百(bai)年老校建設(she)成貴陽的(de)特(te)色名(ming)校”。
貴(gui)陽(yang)市(shi)第(di)二(er)十(shi)一(yi)中(zhong)(zhong)學(xue)(xue)于1905年始建，稱“官立學(xue)(xue)堂(tang)”，后(hou)曾以“省(sheng)(sheng)立模范學(xue)(xue)校”、“省(sheng)(sheng)立貴(gui)陽(yang)一(yi)中(zhong)(zhong)”、“貴(gui)陽(yang)中(zhong)(zhong)學(xue)(xue)”命名(ming)。解放后(hou)更(geng)名(ming)為貴(gui)陽(yang)二(er)中(zhong)(zhong)，1963年學(xue)(xue)校更(geng)名(ming)為貴(gui)陽(yang)市(shi)第(di)二(er)十(shi)一(yi)中(zhong)(zhong)學(xue)(xue)。
