黃芩(拉丁(ding)學名:Scutellaria baicalensis Georgi),別(bie)名山茶根(gen)、土金(jin)茶根(gen),是(shi)唇形科黃芩屬多年生(sheng)(sheng)草本植物;肉質根(gen)莖(jing)肥厚,葉(xie)堅(jian)紙質,披(pi)針形至(zhi)線狀(zhuang)披(pi)針形,總狀(zhuang)花(hua)序在莖(jing)及枝上頂生(sheng)(sheng),花(hua)冠紫、紫紅至(zhi)藍色,花(hua)絲(si)扁(bian)平,花(hua)柱細長,花(hua)盤(pan)環(huan)狀(zhuang),子房(fang)褐色,小堅(jian)果(guo)卵球形,花(hua)果(guo)期(qi)7~9月。
黃芩生(sheng)于(yu)向陽草坡地(di)、休荒地(di)上,海(hai)拔60~1300(1700~2000)米。產于(yu)黑龍江,遼寧(ning),內蒙古,河北(bei),河南,甘肅,陜(shan)西,山西,山東,四川(chuan)等地(di),中國北(bei)方多數省(sheng)區都可種植。俄(e)羅斯(si)(si)東西伯(bo)利(li)亞(ya),蒙古,朝(chao)鮮,日本均有分布。模式標本采(cai)自(zi)俄(e)羅斯(si)(si)。
黃芩的根入藥,味苦、性(xing)寒,有清(qing)熱(re)燥(zao)濕、瀉(xie)火(huo)解毒(du)、止血(xue)(xue)、安(an)胎等功效。主治(zhi)溫(wen)熱(re)病(bing)、上呼吸(xi)道感染、肺(fei)熱(re)咳嗽、濕熱(re)黃膽、肺(fei)炎、痢疾、咳血(xue)(xue)、目赤、胎動不(bu)安(an)、高血(xue)(xue)壓、癰(yong)腫(zhong)癤(jie)瘡等癥(zheng)。黃芩的臨床(chuang)抗(kang)菌性(xing)比黃連好,而(er)且不(bu)產生抗(kang)藥性(xing)。
生于向陽草坡地、休荒地上,海拔(ba)60~1300(1700~2000)米。
黃(huang)芩野生于山頂、山坡、林緣、路旁等向(xiang)陽較干燥(zao)的(de)地(di)(di)方。喜(xi)溫暖,耐(nai)嚴(yan)寒,成年植株(zhu)地(di)(di)下部分(fen)在-35℃低溫下仍能安全越冬,35℃高(gao)(gao)溫不致枯死(si),但不能經受40℃以上連續高(gao)(gao)溫天氣(qi)。耐(nai)旱怕澇,地(di)(di)內(nei)積(ji)水(shui)或雨(yu)水(shui)過(guo)多,生長不良,重者爛根死(si)亡。排水(shui)不良的(de)土地(di)(di)不宜(yi)種植。土壤(rang)以壤(rang)土和沙質(zhi)壤(rang)士,酸堿度以中性(xing)和微堿性(xing)為好,忌(ji)連作。
黃芩主要(yao)分布在山(shan)東(dong)、陜西(xi)、山(shan)西(xi)、甘肅(su)四大產(chan)(chan)區(qu)(qu)(qu),其中(zhong)集中(zhong)在山(shan)西(xi)絳縣南(nan)(nan)凡鎮、運城(cheng)市夏(xia)縣瑤峰鎮、新絳縣萬安鎮、萬榮縣、聞喜縣薛店鎮等(deng)地(di);陜西(xi)商洛、渭(wei)南(nan)(nan)臨渭(wei)區(qu)(qu)(qu)橋南(nan)(nan)鎮、商州市商州區(qu)(qu)(qu)孝(xiao)義鎮、洛南(nan)(nan)縣景村(cun)(cun)鎮、丹鳳縣棣花鎮、商洛市夜村(cun)(cun)鎮、丹鳳縣商鎮等(deng)地(di);山(shan)東(dong)沂蒙(meng)山(shan)區(qu)(qu)(qu)、莒縣庫山(shan)鄉(xiang)、萊蕪(wu)市茶葉(xie)口(kou)鎮、富官莊鄉(xiang)等(deng)地(di);甘肅(su)主產(chan)(chan)隴西(xi)、渭(wei)源、漳縣,次產(chan)(chan)岷縣、宕昌、河西(xi)等(deng)地(di)。
黃芩主(zhu)要分布中國內蒙(meng)中東(dong)部和東(dong)北三省大部,河北承德,內蒙(meng)古(gu)赤峰等幾個(ge)最具規模的主(zhu)產(chan)區(qu),是中國北方野(ye)生中藥材的主(zhu)要產(chan)地之一。
多(duo)年生(sheng)草本;根莖(jing)肥厚,肉質,徑達(da)2厘米(mi),伸長(chang)而分枝。莖(jing)基(ji)部伏地,上(shang)升,高30~120厘米(mi),基(ji)部徑2.5-3毫米(mi),鈍四棱形,具細條紋,近無毛或被(bei)上(shang)曲(qu)至開展的微柔毛,綠色或帶紫色,自基(ji)部多(duo)分枝。
葉堅紙質(zhi),披針形至線狀(zhuang)披針形,長1.5~4.5厘米(mi)(mi),寬0.5~1.2厘米(mi)(mi),頂端鈍(dun),基部圓形,全緣,上(shang)面暗綠色,無毛或疏被貼生至開展的(de)微柔毛,下面色較淡,無毛或沿中脈疏被微柔毛,密被下陷的(de)腺點,側脈4對,與中脈上(shang)面下陷下面凸(tu)出(chu);葉柄短,長2毫米(mi)(mi),腹凹背凸(tu),被微柔毛。
花(hua)序在(zai)莖及枝上(shang)頂生,總狀,長(chang)(chang)(chang)7~15厘米(mi),常(chang)再于(yu)莖頂聚(ju)成圓錐(zhui)花(hua)序;花(hua)梗長(chang)(chang)(chang)3毫(hao)(hao)(hao)米(mi),與(yu)序軸均被(bei)(bei)(bei)微(wei)柔(rou)(rou)毛(mao)(mao)(mao);苞片(pian)(pian)(pian)(pian)下(xia)部(bu)者(zhe)似(si)葉,上(shang)部(bu)者(zhe)遠較小(xiao),卵圓狀披(pi)針形(xing)(xing)至披(pi)針形(xing)(xing),長(chang)(chang)(chang)4~11毫(hao)(hao)(hao)米(mi),近于(yu)無毛(mao)(mao)(mao)。花(hua)萼(e)開花(hua)時長(chang)(chang)(chang)4毫(hao)(hao)(hao)米(mi),盾(dun)片(pian)(pian)(pian)(pian)高(gao)1.5毫(hao)(hao)(hao)米(mi),外面(mian)密被(bei)(bei)(bei)微(wei)柔(rou)(rou)毛(mao)(mao)(mao),萼(e)緣被(bei)(bei)(bei)疏柔(rou)(rou)毛(mao)(mao)(mao),內面(mian)無毛(mao)(mao)(mao),果時花(hua)萼(e)長(chang)(chang)(chang)5毫(hao)(hao)(hao)米(mi),有高(gao)4毫(hao)(hao)(hao)米(mi)的盾(dun)片(pian)(pian)(pian)(pian)。花(hua)冠(guan)紫、紫紅(hong)至藍色,長(chang)(chang)(chang)2.3~3厘米(mi),外面(mian)密被(bei)(bei)(bei)具腺短柔(rou)(rou)毛(mao)(mao)(mao),內面(mian)在(zai)囊(nang)狀膨大處被(bei)(bei)(bei)短柔(rou)(rou)毛(mao)(mao)(mao);冠(guan)筒(tong)近基(ji)部(bu)明(ming)顯膝曲,中部(bu)徑(jing)1.5毫(hao)(hao)(hao)米(mi),至喉部(bu)寬達6毫(hao)(hao)(hao)米(mi);冠(guan)檐2唇(chun)形(xing)(xing),上(shang)唇(chun)盔狀,先端微(wei)缺,下(xia)唇(chun)中裂(lie)(lie)片(pian)(pian)(pian)(pian)三角狀卵圓形(xing)(xing),寬7.5毫(hao)(hao)(hao)米(mi),兩側裂(lie)(lie)片(pian)(pian)(pian)(pian)向(xiang)上(shang)唇(chun)靠合。雄蕊4,稍露出,前對較長(chang)(chang)(chang),具半藥(yao),退化半藥(yao)不明(ming)顯,后對較短,具全藥(yao),藥(yao)室(shi)裂(lie)(lie)口(kou)具白色髯毛(mao)(mao)(mao),背部(bu)具泡狀毛(mao)(mao)(mao);花(hua)絲扁平,中部(bu)以(yi)下(xia)前對在(zai)內側后對在(zai)兩側被(bei)(bei)(bei)小(xiao)疏柔(rou)(rou)毛(mao)(mao)(mao)。花(hua)柱細(xi)長(chang)(chang)(chang),先端銳尖,微(wei)裂(lie)(lie)。花(hua)盤(pan)環狀,高(gao)0.75毫(hao)(hao)(hao)米(mi),前方稍增大,后方延伸成極短子(zi)房柄。子(zi)房褐色,無毛(mao)(mao)(mao)。
小(xiao)堅果(guo)卵(luan)球形,高1.5毫(hao)米,徑1毫(hao)米,黑褐色,具(ju)瘤(liu),腹面近基部具(ju)果(guo)臍。花期7-8月,果(guo)期8-9月。
根(gen)的(de)(de)生(sheng)(sheng)長(chang):黃(huang)芩為(wei)直(zhi)根(gen)系,主(zhu)(zhu)(zhu)(zhu)根(gen)在前三年生(sheng)(sheng)長(chang)正常,其主(zhu)(zhu)(zhu)(zhu)根(gen)長(chang)度、粗度、鮮重(zhong)(zhong)和干重(zhong)(zhong)均逐年增加,主(zhu)(zhu)(zhu)(zhu)根(gen)中(zhong)黃(huang)芩苷含(han)量較高。第四年以(yi)后(hou)(hou),生(sheng)(sheng)長(chang)速度開始變慢,部分主(zhu)(zhu)(zhu)(zhu)根(gen)開始出現(xian)枯心(xin),以(yi)后(hou)(hou)逐年加重(zhong)(zhong),八年生(sheng)(sheng)的(de)(de)家重(zhong)(zhong)黃(huang)芩幾(ji)乎所有主(zhu)(zhu)(zhu)(zhu)根(gen)及較粗的(de)(de)側根(gen)全(quan)部枯心(xin),而(er)且黃(huang)芩苷的(de)(de)含(han)量也大幅度降低。
莖、葉(xie)生(sheng)長(chang)(chang)(chang):出苗后(hou),主(zhu)莖逐漸長(chang)(chang)(chang)高,葉(xie)數逐漸增加,隨(sui)后(hou)形成分(fen)枝并現蕾、開花、結(jie)實。5~6月為(wei)莖葉(xie)生(sheng)長(chang)(chang)(chang)期,一年生(sheng)黃芩(qin)主(zhu)莖約可長(chang)(chang)(chang)出30對(dui)葉(xie),其中前五對(dui)葉(xie)每4~6天(tian)長(chang)(chang)(chang)出1對(dui),其后(hou)葉(xie)片每2~3天(tian)長(chang)(chang)(chang)出1對(dui)。
開(kai)(kai)花(hua)(hua)結果:一年生植株一般出苗后2個月開(kai)(kai)始(shi)現蕾(lei),二年生及其(qi)以后的(de)黃芩,多于(yu)返(fan)青出苗后70~80天開(kai)(kai)始(shi)現蕾(lei),現蕾(lei)后10天左右開(kai)(kai)始(shi)開(kai)(kai)花(hua)(hua),40天左右果實開(kai)(kai)始(shi)成熟,如環境條(tiao)件(jian)適宜(yi)黃芩開(kai)(kai)花(hua)(hua)結實可持續(xu)到霜枯期(qi)。
采取(qu)種子直播時,當(dang)幼(you)苗(miao)(miao)長(chang)到4厘(li)米高時要間去過(guo)密和瘦弱(ruo)的小苗(miao)(miao),按株距10厘(li)米定苗(miao)(miao)。育苗(miao)(miao)地(di)不(bu)必間苗(miao)(miao)。
幼(you)苗出土(tu)后,應及時(shi)松土(tu)除(chu)(chu)草,并結合松土(tu)向幼(you)苗四周(zhou)適(shi)當(dang)培(pei)土(tu),保持疏松、無雜草,一(yi)年需要除(chu)(chu)草3-4次。
苗高10-15厘(li)米時,追肥1次,施用量為每畝(mu)用人畜糞水1500-2000千(qian)克(ke)(ke)(ke)。6月底(di)-7月初,每畝(mu)追施過(guo)磷酸鈣20千(qian)克(ke)(ke)(ke)、尿(niao)素5千(qian)克(ke)(ke)(ke),行間開溝施下,覆土后(hou)(hou)澆(jiao)水。次年(nian)收(shou)獲的(de)待植株枯(ku)萎后(hou)(hou),于(yu)行間開溝每畝(mu)追施腐熟廄肥2000千(qian)克(ke)(ke)(ke)、過(guo)磷酸鈣20千(qian)克(ke)(ke)(ke)、尿(niao)素5千(qian)克(ke)(ke)(ke)、草木灰(hui)150千(qian)克(ke)(ke)(ke),然后(hou)(hou)覆土蓋平。
黃芩耐(nai)旱怕澇,雨季需注意(yi)排水,田間不可積(ji)水,否(fou)則易爛(lan)根。遇嚴重(zhong)干旱時或追肥后(hou),可適當澆水。
在抽出花序前,將花梗減掉,可減少養(yang)分消耗(hao),促使根(gen)系生長(chang),提高產量。
種子繁殖:
⑴直播法
種子繁殖以直(zhi)播(bo)為主,直(zhi)播(bo)黃芩(qin)根系(xi)直(zhi),根叉少,商品外(wai)觀(guan)品質好(hao),同時省(sheng)工。
直播多于春季(ji)進行,一般(ban)在地下(xia)5厘米(mi)地溫穩定在12℃-15℃時播種,北方地區多在4月上中旬前(qian)后。
⑵育苗移栽法
育(yu)苗(miao)移栽(zai)法可節省種子,延長生長時間,利于(yu)確保(bao)全(quan)苗(miao),但(dan)較(jiao)為費工,同(tong)時移栽(zai)黃芩(qin)主根較(jiao)短,根叉較(jiao)多,商(shang)品外(wai)觀品質差,一般(ban)在種子昂貴或(huo)者旱地缺水直播難以(yi)出苗(miao)保(bao)苗(miao)時采用。
扦插(cha)繁殖(zhi):扦插(cha)雖可(ke)繁殖(zhi),但生產中很少采(cai)用。扦插(cha)成敗的(de)關鍵在于扦插(cha)季(ji)(ji)節(jie)和(he)取(qu)條部(bu)分。扦插(cha)時間(jian)以(yi)春季(ji)(ji)5-6月份(fen)扦插(cha)成活(huo)率高(gao)。插(cha)條應(ying)選莖(jing)尖半木質(zhi)化(hua)的(de)幼嫩(nen)部(bu)分,扦插(cha)成活(huo)率可(ke)達90%以(yi)上。
分根(gen)(gen)(gen)(gen)繁(fan)殖:即(ji)挖取洞未萌(meng)發的(de)3年(nian)生黃芩根(gen)(gen)(gen)(gen)莖(jing),切取主根(gen)(gen)(gen)(gen)留(liu)供(gong)藥用(yong),然后根(gen)(gen)(gen)(gen)據根(gen)(gen)(gen)(gen)莖(jing)生長的(de)自然形狀分切成若(ruo)干(gan)塊,每塊有(you)芽眼2-3個即(ji)可栽種。分根(gen)(gen)(gen)(gen)繁(fan)殖雖(sui)然生長快,但繁(fan)殖系數(shu)太(tai)低,生產中很少采用(yong)。
病害有葉(xie)枯病,可清潔田園,發(fa)端正(zheng)初期噴灑1:1:200波爾多(duo)(duo)液,或(huo)用(yong)50%多(duo)(duo)菌靈1000倍液防治(zhi)。
根腐病(bing)(bing)(bing),注(zhu)意排水,實行輪作(zuo);及早(zao)撥出病(bing)(bing)(bing)株燒毀,病(bing)(bing)(bing)株處土壤用(yong)石灰(hui)消(xiao)毒。
蟲害有黃芩舞(wu)蛾,可用(yong)90%敵百蟲防治。
付方
性味:苦,寒。
①《本(ben)經》:味苦,平(ping)。
②《別(bie)錄》:大(da)寒,無毒(du)。
③《藥(yao)性(xing)論(lun)》:味(wei)苦(ku)甘(gan)。
歸經:入心、肺、膽、大腸經。
①《品匯精要》:行手太陰、陽明經。
②《綱目(mu)》:入手(shou)少(shao)陰、陽明,手(shou)足(zu)太陰、少(shao)陽六經。
③《雷(lei)公炮制(zhi)藥性(xing)解》:入肺、大腸、膀胱、膽四經。
瀉實(shi)火,除濕熱(re)(re),止血(xue),安胎。治壯熱(re)(re)煩渴,肺熱(re)(re)咳嗽,濕熱(re)(re)瀉痢,黃疸,熱(re)(re)淋,吐、衄、崩、漏,目赤腫痛,胎動不安,癰腫疔瘡。
①《本(ben)經》:主諸熱黃(huang)疸,腸澼,泄利(li),逐水,下血閉,(治)惡瘡,疽蝕,火(huo)瘍。
②《別(bie)錄》:療(liao)痰熱(re),胃中熱(re),小腹絞痛,消谷(gu),利小腸,女子(zi)血(xue)閉(bi),淋露下血(xue),小兒(er)腹痛。
③陶弘景:治奔豚,臍下熱痛。
④《藥(yao)性論(lun)》:能治熱(re)毒,骨蒸,寒(han)熱(re)往來,腸胃不(bu)利,破壅氣,治五淋,令人宣暢,去關節煩(fan)悶,解熱(re)渴,治熱(re)腹中疞痛,心腹堅脹。
⑤《日華子本草》:下氣,主天行(xing)熱疾,疔瘡,排膿。治乳(ru)癰(yong),發(fa)背。
⑥《珍珠(zhu)囊》:除陽有余,涼心去熱,通寒格(ge)。
⑦李杲:治發熱口苦。
⑧《滇南本草》:上行(xing)(xing)瀉肺火(huo),下行(xing)(xing)瀉膀胱火(huo),(治)男(nan)子五(wu)淋,女子暴崩(beng),調經清熱,胎有火(huo)熱不安,清胎熱,除(chu)六經實(shi)火(huo)實(shi)熱。
⑨《綱目》:治風熱濕熱頭疼,奔豚熱痛,火(huo)咳,肺痿喉腥,諸失血。
⑩《本草正(zheng)》:枯者清(qing)上焦之(zhi)火,消痰利氣,定喘(chuan)嗽,止失血(xue),退往來(lai)寒熱(re)(re),風熱(re)(re)濕熱(re)(re),頭痛,解(jie)瘟疫,清(qing)咽,療肺痿(wei)肺癰(yong),乳(ru)癰(yong)發背,尤祛肌表之(zhi)熱(re)(re),故治斑疹、鼠瘺,瘡瘍、赤眼;實者涼下焦之(zhi)熱(re)(re),能(neng)除赤痢(li),熱(re)(re)蓄膀胱,五淋澀痛,大(da)腸閉結,便血(xue)、漏血(xue)。
⑾《科學的民(min)間(jian)藥草》:外(wai)洗創口(kou),有防腐作用。
內服:煎湯,1~3錢;或(huo)(huo)入丸(wan)、散(san)。外用:煎水洗(xi)或(huo)(huo)研末撤。
黃(huang)(huang)(huang)(huang)(huang)芩(qin)(qin)(qin)(qin)根含黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)類化合物(wu):黃(huang)(huang)(huang)(huang)(huang)芩(qin)(qin)(qin)(qin)素(su)(su)(baicalein),黃(huang)(huang)(huang)(huang)(huang)芩(qin)(qin)(qin)(qin)新素(su)(su)(neobaicalein),即(ji)黃(huang)(huang)(huang)(huang)(huang)芩(qin)(qin)(qin)(qin)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)Ⅱ(skullcapflavoneⅡ),黃(huang)(huang)(huang)(huang)(huang)芩(qin)(qin)(qin)(qin)甙(dai)(dai)(baicalin),漢(han)黃(huang)(huang)(huang)(huang)(huang)芩(qin)(qin)(qin)(qin)素(su)(su)(wogonin),漢(han)黃(huang)(huang)(huang)(huang)(huang)芩(qin)(qin)(qin)(qin)甙(dai)(dai)(wogono-side),木蝴(hu)蝶(die)素(su)(su)A(oroxylin,oroxylin A),7-甲(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)芩(qin)(qin)(qin)(qin)素(su)(su)(7-methoxbaic alein),黃(huang)(huang)(huang)(huang)(huang)芩(qin)(qin)(qin)(qin)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(skullcapflavone)Ⅰ,二(er)氫木蝴(hu)蝶(die)素(su)(su)A(dihydrooroxylin A),白楊素(su)(su)(chrysin),2,5,8-三(san)(san)(san)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-7-甲(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(2,5,8-trihydroxy-7-methoxy-flavone),2,5,8-三(san)(san)(san)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-6,7-二(er)甲(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(2,5,8-trihydroxy-6,7-dimethoxyflavone),4,5,7-三(san)(san)(san)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-6-甲(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)烷(wan)酮(tong)(tong)(tong)(tong)(tong)(4,5,7-trhydroxy-6-methoxyflavanone),2,3,5,6,7-五羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)烷(wan)酮(tong)(tong)(tong)(tong)(tong)(2,3,5,6,7-pentahydroxyflavanone),漢(han)黃(huang)(huang)(huang)(huang)(huang)芩(qin)(qin)(qin)(qin)素(su)(su)-5-β-D-葡(pu)(pu)(pu)萄(tao)糖(tang)甙(dai)(dai)(wogonin-5-β-D-glucoside),2-(3-羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-4-甲(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)苯基(ji)(ji)(ji))-乙(yi)基(ji)(ji)(ji)-1-O-α-L-鼠李糖(tang)基(ji)(ji)(ji)(1→3)-β-D(4-阿(a)魏(wei)酰基(ji)(ji)(ji))-葡(pu)(pu)(pu)萄(tao)糖(tang)〔2-(3-hydroxy-4-methoxyphenyl)ethyl-1-O-α-L-rhamnosyl(1→3)-β-D-(4-feruloyl)glucoside〕,白楊素(su)(su)-6-C-α-L-阿(a)拉伯糖(tang)甙(dai)(dai)(chrysin-6-C-β-D-glucoside-8-C-β-L-arabinoside),白楊素(su)(su)-6-C-α-L-阿(a)拉伯糖(tang)甙(dai)(dai)-8-C-β-D-葡(pu)(pu)(pu)萄(tao)糖(tang)甙(dai)(dai)(chrysin-6-C-α-L-arabi-noside-8-C-β-D-glucoside),(2S)-2,5,6,7-四(si)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)烷(wan)酮(tong)(tong)(tong)(tong)(tong)〔(2S)-25,6,7-terahydroxyflavanone〕,5,7,2,6-四(si)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5,7,2,6-tetrahydroxyflavone),5,8-二(er)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-6,7-二(er)甲(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5,8-dihydroxy-6,7-drimethoxyflavone),5,7,4-三(san)(san)(san)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-8-甲(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5,7,4-trihydroxy-8-methoxyflavone),木蝴(hu)蝶(die)素(su)(su)A-7-O-葡(pu)(pu)(pu)萄(tao)糖(tang)醛酸甙(dai)(dai)(oroxylinA-7-O-glucuronide),5,7,2-三(san)(san)(san)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)甲(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5,7,2-trihyroxy-6-methoxyflavone),5,2-二(er)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-6,7,8-三(san)(san)(san)甲(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5,2-dihydroxy-6,7,8-trimethoxyfla-vone),5-閎基(ji)(ji)(ji)-7,8-二(er)甲(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5-hydroxy-7,8-dimethoxy-flavone),去甲(jia)漢(han)黃(huang)(huang)(huang)(huang)(huang)芩(qin)(qin)(qin)(qin)素(su)(su)(norwogonin),二(er)氫黃(huang)(huang)(huang)(huang)(huang)芩(qin)(qin)(qin)(qin)素(su)(su)(dihydro-baicalin),5,7,2-三(san)(san)(san)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5,7,2-trihydroxyflavone),5,7,2-三(san)(san)(san)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-8,6-二(er)甲(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5,7,2-trihydroxy-8,6-dimethoxyflavone),5,7,2,5-四(si)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-8,6-二(er)甲(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)即(ji)粘毛(mao)(mao)(mao)黃(huang)(huang)(huang)(huang)(huang)芩(qin)(qin)(qin)(qin)素(su)(su)Ⅲ(5,7,2,5-tetrahydroxy-8,6-dimethoxyflavone,vis-ciduiin Ⅲ,5,2,5-三(san)(san)(san)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)三(san)(san)(san)甲(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5,2,5-trihy-droxy-6,7,8-trimethoxyflavone),黃(huang)(huang)(huang)(huang)(huang)芩(qin)(qin)(qin)(qin)素(su)(su)-7-O-β-D-吡喃(nan)(nan)葡(pu)(pu)(pu)萄(tao)糖(tang)甙(dai)(dai)(baicalein-7-O-β-D-glucopyranoside),5,7,2-三(san)(san)(san)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-8-甲(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5,7,2-trhiyroxy-8-methoxyflavone),5,7,2,3-四(si)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5,7,2,3-trihydroxy-6-methoxyflavone),5,7,2,3-四(si)閎基(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5,7,2,3-tetrahydroxyflavone),3,5,7,2,5,6-五羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(3,5,7,2,5,6-pentahydroxyflavone)即(ji)粘毛(mao)(mao)(mao)黃(huang)(huang)(huang)(huang)(huang)芩(qin)(qin)(qin)(qin)素(su)(su)Ⅰ(viscidulin Ⅰ),(2S)-7,2,6-三(san)(san)(san)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-5-甲(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)烷(wan)酮(tong)(tong)(tong)(tong)(tong)〔(2S)-7,2,6-trihydroxy-5-methoxyflavanone〕,2,6,2,4-四(si)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-6-甲(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)查爾酮(tong)(tong)(tong)(tong)(tong)(2,6,2,4-tetrahydroxy-6-methoxychalcone),5,7,2,5-四(si)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5,7,2,5-tetrahydroxyflavone),左(zuo)旋圣(sheng)草素(su)(su)(eriodictyol),半枝蓮種素(su)(su)(rivularin)及粘毛(mao)(mao)(mao)黃(huang)(huang)(huang)(huang)(huang)芩(qin)(qin)(qin)(qin)素(su)(su)Ⅲ-2-O-β-D-吡喃(nan)(nan)葡(pu)(pu)(pu)萄(tao)糖(tang)甙(dai)(dai)(viscidulin Ⅲ-2-O-β-D-glucoplyranoside)等(deng)。另(ling)外還含β-谷甾(zai)醇(chun)(chun)(β-sitosterol),菜油甾(zai)醇(chun)(chun)(campesterol)及豆甾(zai)醇(chun)(chun)(stigmasterol)。
抗(kang)菌(jun)(jun)(jun)作用(yong)(yong):黃(huang)芩(qin)(qin)(qin)煎(jian)劑(ji)100%濃(nong)度(du),平(ping)板法試(shi)(shi)驗(yan),對痢疾(ji)(ji)桿(gan)(gan)菌(jun)(jun)(jun)、傷寒(han)(han)桿(gan)(gan)菌(jun)(jun)(jun)、副傷寒(han)(han)桿(gan)(gan)菌(jun)(jun)(jun)、霍(huo)亂(luan)(luan)弧(hu)菌(jun)(jun)(jun)、大(da)腸(chang)桿(gan)(gan)菌(jun)(jun)(jun)、變形(xing)桿(gan)(gan)菌(jun)(jun)(jun)、綠膿桿(gan)(gan)菌(jun)(jun)(jun)、葡(pu)萄球(qiu)(qiu)(qiu)菌(jun)(jun)(jun)、溶血(xue)性(xing)璉球(qiu)(qiu)(qiu)菌(jun)(jun)(jun)(a,B)、肺炎(yan)雙球(qiu)(qiu)(qiu)菌(jun)(jun)(jun)、白(bai)喉桿(gan)(gan)菌(jun)(jun)(jun)等有(you)抑(yi)制作用(yong)(yong)。黃(huang)芩(qin)(qin)(qin)煎(jian)劑(ji)試(shi)(shi)管法試(shi)(shi)驗(yan)1:1280濃(nong)度(du)可抑(yi)制傷寒(han)(han)桿(gan)(gan)菌(jun)(jun)(jun)、溶血(xue)性(xing)鏈球(qiu)(qiu)(qiu)菌(jun)(jun)(jun)a,1:640濃(nong)度(du)抑(yi)制溶血(xue)性(xing)鏈球(qiu)(qiu)(qiu)菌(jun)(jun)(jun)B,肺炎(yan)雙球(qiu)(qiu)(qiu)菌(jun)(jun)(jun)及福(fu)氏(shi)(shi)痢疾(ji)(ji)桿(gan)(gan)菌(jun)(jun)(jun)、人結核桿(gan)(gan)菌(jun)(jun)(jun)H37,1:320濃(nong)度(du)可抑(yi)制霍(huo)亂(luan)(luan)弧(hu)菌(jun)(jun)(jun)、志賀氏(shi)(shi)痢疾(ji)(ji)桿(gan)(gan)菌(jun)(jun)(jun);1:80濃(nong)度(du)時宋內(nei)氏(shi)(shi)痢疾(ji)(ji)桿(gan)(gan)菌(jun)(jun)(jun)有(you)抑(yi)制作用(yong)(yong)。黃(huang)芩(qin)(qin)(qin)醇(chun)浸液(ye)(ye)0.5g/ml或0。05g/ml,用(yong)(yong)瓊脂斜(xie)面培養,藥液(ye)(ye)與培養基1:1混合,對綠膿桿(gan)(gan)菌(jun)(jun)(jun)有(you)抑(yi)制作用(yong)(yong)。黃(huang)芩(qin)(qin)(qin)醇(chun)浸液(ye)(ye)2g/ml濃(nong)度(du),平(ping)皿法試(shi)(shi)驗(yan)對大(da)腸(chang)桿(gan)(gan)菌(jun)(jun)(jun)、桔草桿(gan)(gan)菌(jun)(jun)(jun)、金黃(huang)色葡(pu)萄球(qiu)(qiu)(qiu)菌(jun)(jun)(jun)有(you)抑(yi)制作用(yong)(yong)。黃(huang)芩(qin)(qin)(qin)煎(jian)劑(ji)、醇(chun)提(ti)劑(ji)1g/ml濃(nong)度(du),用(yong)(yong)平(ping)板法試(shi)(shi)驗(yan)時對腦膜(mo)炎(yan)球(qiu)(qiu)(qiu)菌(jun)(jun)(jun)均有(you)抑(yi)作用(yong)(yong)。
抗(kang)真菌(jun)作用:黃(huang)(huang)芩煎液,試管斜面法試驗4%濃(nong)(nong)(nong)度(du)抑(yi)(yi)制(zhi)(zhi)狗小牙胞菌(jun)及堇色毛(mao)(mao)癬(xian)(xian)菌(jun),8%濃(nong)(nong)(nong)度(du)抑(yi)(yi)制(zhi)(zhi)許蘭氏(shi)(shi)(shi)(shi)黃(huang)(huang)癬(xian)(xian)菌(jun),10%濃(nong)(nong)(nong)度(du)抑(yi)(yi)制(zhi)(zhi)許蘭氏(shi)(shi)(shi)(shi)黃(huang)(huang)癬(xian)(xian)菌(jun)蒙古變(bian)種,15%濃(nong)(nong)(nong)度(du)抑(yi)(yi)制(zhi)(zhi)共心性毛(mao)(mao)癬(xian)(xian)菌(jun)及鐵銹色毛(mao)(mao)癬(xian)(xian)菌(jun)。黃(huang)(huang)芩水浸劑1:3濃(nong)(nong)(nong)度(du)在試管內(nei)對堇色毛(mao)(mao)癬(xian)(xian)菌(jun)、同(tong)心性毛(mao)(mao)癬(xian)(xian)菌(jun),許蘭氏(shi)(shi)(shi)(shi)黃(huang)(huang)癬(xian)(xian)菌(jun)、奧(ao)杜盎氏(shi)(shi)(shi)(shi)小芽胞癬(xian)(xian)菌(jun)、羊毛(mao)(mao)樣小芽胞癬(xian)(xian)菌(jun)、紅色表(biao)皮癬(xian)(xian)菌(jun)、K、W、氏(shi)(shi)(shi)(shi)表(biao)皮癬(xian)(xian)菌(jun)、星形(xing)奴卡氏(shi)(shi)(shi)(shi)菌(jun)等有不同(tong)程度(du)抑(yi)(yi)菌(jun)作用。
抗病毒作(zuo)用(yong)(yong):黃芩煎(jian)劑25-100%濃度,體外試驗(yan)對(dui)乙(yi)型肝炎病毒DNA復制有(you)抑(yi)制作(zuo)用(yong)(yong)。
抗炎(yan)抗變(bian)態反應:黃(huang)芩(qin)70%乙醇提取(qu)物(wu)200,500mg/kg灌胃黃(huang)芩(qin)素(su)、黃(huang)芩(qin)甙、漢(han)黃(huang)芩(qin)素(su)50,100mg/kg灌胃,可抑制醋酸引起(qi)的小(xiao)鼠(shu)腹腔滲出增加(jia),對48/80(一種化合物(wu)名稱(cheng),Sigma生產(chan))引起(qi)的大鼠(shu)足腫也(ye)有(you)(you)抑制作(zuo)用,黃(huang)芩(qin)70%乙醇提取(qu)物(wu)500mg/kg灌胃,黃(huang)芩(qin)素(su)、黃(huang)芩(qin)甙及漢(han)黃(huang)芩(qin)素(su)100mg/kg灌胃對大鼠(shu)佐劑性關節炎(yan)有(you)(you)抑制作(zuo)用。黃(huang)芩(qin)水提物(wu)100,200mg/kg灌胃,對大鼠(shu)被動皮膚(fu)過敏(min)反應(PCA)有(you)(you)抑制作(zuo)用,但對氯(lv)化苦引起(qi)的小(xiao)鼠(shu)接觸(chu)皮炎(yan)(耳(er)腫脹)無明(ming)顯影響(xiang)。
對(dui)(dui)中樞神(shen)經系統(tong)的(de)作(zuo)用(yong):黃(huang)(huang)芩(qin)煎劑4g/kg腹(fu)腔注射(she),對(dui)(dui)小鼠防御性(xing)(xing)條(tiao)件反(fan)射(she)可使(shi)陽性(xing)(xing)反(fan)射(she)時延長,而對(dui)(dui)非(fei)條(tiao)件反(fan)射(she)及分化無影響,說明(ming)(ming)黃(huang)(huang)芩(qin)可加強(qiang)皮層抑制過程。黃(huang)(huang)芩(qin)煎劑2g/kg,對(dui)(dui)傷(shang)(shang)寒混合疫(yi)苗(miao)致熱(re)家兔(tu)有解熱(re)作(zuo)用(yong)。但(dan)也有報道黃(huang)(huang)芩(qin)水煎劑或酒(jiu)浸劑5-9g/只灌胃,或2g/只im,均(jun)不能證明(ming)(ming)黃(huang)(huang)芩(qin)對(dui)(dui)傷(shang)(shang)寒疫(yi)苗(miao)致熱(re)家兔(tu)有解熱(re)作(zuo)用(yong)。
對心血(xue)管(guan)的作(zuo)(zuo)(zuo)用(yong)(yong):黃(huang)芩(qin)醇提液1g/kg靜脈(mo)注(zhu)射,可使麻醉(zui)(zui)犬(quan)血(xue)壓(ya)下降。黃(huang)芩(qin)煎劑(ji)0。06g/kg靜脈(mo)注(zhu)射,對麻醉(zui)(zui)犬(quan)有(you)明顯降壓(ya)作(zuo)(zuo)(zuo)用(yong)(yong)。黃(huang)芩(qin)素(su)20mg/kg靜脈(mo)注(zhu)射,可使麻醉(zui)(zui)犬(quan)血(xue)壓(ya)下降40-50%。黃(huang)芩(qin)浸劑(ji)灌(guan)胃(wei)/kg灌(guan)胃(wei),3次/天,連續4周,使慢性腎(shen)(shen)性高血(xue)壓(ya)犬(quan)血(xue)壓(ya)下降,心率變慢。黃(huang)芩(qin)甙2×10(-4)mol/l,在豚鼠離體主(zhu)動脈(mo)條、肺動脈(mo)條、氣管(guan)條及(ji)右(you)心房(fang)均(jun)有(you)競爭性的拮抗(kang)腎(shen)(shen)上腺素(su),去(qu)甲腎(shen)(shen)上腺素(su)及(ji)多巴(ba)胺引起的收縮作(zuo)(zuo)(zuo)用(yong)(yong),也拮抗(kang)異丙腎(shen)(shen)上腺素(su)舒張(zhang)氣管(guan)和增加右(you)心房(fang)自發頻率作(zuo)(zuo)(zuo)用(yong)(yong),提示黃(huang)芩(qin)甙對a,B1,B2受(shou)體均(jun)有(you)阻斷(duan)作(zuo)(zuo)(zuo)用(yong)(yong)。
抗(kang)血(xue)(xue)小(xiao)(xiao)板(ban)(ban)(ban)(ban)(ban)聚集(ji)(ji)及抗(kang)凝:黃芩(qin)(qin)素(su)(su)(su)、漢黃芩(qin)(qin)素(su)(su)(su)、千層紙(zhi)素(su)(su)(su)A、黃芩(qin)(qin)黃酮Ⅱ及白(bai)楊(yang)素(su)(su)(su)(chrysin)于(yu)濃度1。0mM時,均(jun)可(ke)抑制(zhi)(zhi)膠原(yuan)(yuan)誘(you)導的大(da)鼠血(xue)(xue)小(xiao)(xiao)板(ban)(ban)(ban)(ban)(ban)聚集(ji)(ji),白(bai)楊(yang)素(su)(su)(su)對ADP誘(you)導的血(xue)(xue)小(xiao)(xiao)板(ban)(ban)(ban)(ban)(ban)聚集(ji)(ji)也(ye)有抑制(zhi)(zhi)作用(yong),黃芩(qin)(qin)素(su)(su)(su)及漢黃芩(qin)(qin)素(su)(su)(su)對花生四烯(xi)酸誘(you)導的血(xue)(xue)小(xiao)(xiao)板(ban)(ban)(ban)(ban)(ban)聚集(ji)(ji)也(ye)有抑制(zhi)(zhi)作用(yong),黃芩(qin)(qin)素(su)(su)(su)及黃芩(qin)(qin)甙對凝血(xue)(xue)酶誘(you)導的纖維蛋白(bai)原(yuan)(yuan)轉化(hua)為纖維蛋白(bai)也(ye)抑制(zhi)(zhi);黃芩(qin)(qin)素(su)(su)(su)及黃芩(qin)(qin)甙20,50mg/kg灌(guan)胃,對內毒素(su)(su)(su)誘(you)導的大(da)鼠彌漫性血(xue)(xue)管內凝血(xue)(xue),可(ke)以防止血(xue)(xue)小(xiao)(xiao)板(ban)(ban)(ban)(ban)(ban)及纖維蛋白(bai)原(yuan)(yuan)含(han)量的降低。
降(jiang)(jiang)血(xue)(xue)脂:黃(huang)(huang)(huang)芩(qin)(qin)(qin)水(shui)浸液10%2ml/只灌胃,連續給藥7周,可(ke)使膽固(gu)醇(chun)(chun)喂飼(si)的家兔血(xue)(xue)清膽固(gu)醇(chun)(chun)含(han)(han)量下降(jiang)(jiang)。黃(huang)(huang)(huang)芩(qin)(qin)(qin)素、黃(huang)(huang)(huang)芩(qin)(qin)(qin)甙100mg/kg灌胃,可(ke)降(jiang)(jiang)低實驗性(xing)高血(xue)(xue)脂大鼠(shu)玉米油(you)(you)-膽固(gu)醇(chun)(chun)-膽酸喂飼(si)血(xue)(xue)清游離脂肪酸、甘(gan)(gan)(gan)(gan)油(you)(you)三(san)酯及肝(gan)甘(gan)(gan)(gan)(gan)油(you)(you)三(san)酯的含(han)(han)量,黃(huang)(huang)(huang)芩(qin)(qin)(qin)黃(huang)(huang)(huang)酮Ⅱ100mg/kg灌胃,可(ke)降(jiang)(jiang)低血(xue)(xue)清總膽固(gu)醇(chun)(chun)及肝(gan)甘(gan)(gan)(gan)(gan)油(you)(you)三(san)酯的含(han)(han)量,增加(jia)血(xue)(xue)清高密度脂蛋白-膽固(gu)醇(chun)(chun)(HDL-ch)的含(han)(han)量,漢黃(huang)(huang)(huang)芩(qin)(qin)(qin)素100mg/kg灌胃,可(ke)防止肝(gan)甘(gan)(gan)(gan)(gan)油(you)(you)三(san)酯的沉積(ji)并增加(jia)血(xue)(xue)清HDL-ch的含(han)(han)量。黃(huang)(huang)(huang)芩(qin)(qin)(qin)素、黃(huang)(huang)(huang)芩(qin)(qin)(qin)甙100mg/kg灌胃,對乙醇(chun)(chun)引起(qi)的高血(xue)(xue)脂大鼠(shu),可(ke)降(jiang)(jiang)低肝(gan)總膽固(gu)醇(chun)(chun)、游離膽固(gu)醇(chun)(chun)及甘(gan)(gan)(gan)(gan)油(you)(you)三(san)酯含(han)(han)量,漢黃(huang)(huang)(huang)芩(qin)(qin)(qin)素能(neng)(neng)降(jiang)(jiang)低血(xue)(xue)清甘(gan)(gan)(gan)(gan)油(you)(you)三(san)酯的水(shui)平,黃(huang)(huang)(huang)芩(qin)(qin)(qin)素能(neng)(neng)增加(jia)血(xue)(xue)清HDL-ch含(han)(han)量。
保肝、利膽(dan)(dan)、抗(kang)氧(yang)化(hua):黃(huang)(huang)(huang)(huang)芩(qin)(qin)甲醇提(ti)取物(wu)1000mg/kg腹腔注(zhu)射,對異硫(liu)氰酸萘酯(ANIT)引起的大鼠(shu)(shu)肝損(sun)害有抑(yi)制(zhi)(zhi)作(zuo)用(yong),可(ke)抑(yi)制(zhi)(zhi)血清膽(dan)(dan)紅素的增加(jia)。黃(huang)(huang)(huang)(huang)芩(qin)(qin)醇提(ti)物(wu)50,100mg/kg,黃(huang)(huang)(huang)(huang)芩(qin)(qin)甙50,100mg/kg灌胃,對家兔有利膽(dan)(dan)作(zuo)用(yong)。漢(han)黃(huang)(huang)(huang)(huang)芩(qin)(qin)素10(-4)-10(-6)mol/l濃度體外試驗,對大鼠(shu)(shu)肝微粒體脂質過氧(yang)化(hua)有抑(yi)制(zhi)(zhi)作(zuo)用(yong),使丙二醛(MDA)含量下降(jiang)。黃(huang)(huang)(huang)(huang)芩(qin)(qin)素及黃(huang)(huang)(huang)(huang)芩(qin)(qin)甙2。5×10(-4)mol/l,1.0×10(-4)mol/l,漢(han)黃(huang)(huang)(huang)(huang)芩(qin)(qin)素2.5×10(-4)mol/l,黃(huang)(huang)(huang)(huang)芩(qin)(qin)黃(huang)(huang)(huang)(huang)酮(tong)Ⅱ2。5×10(-4)mol/l,漢(han)黃(huang)(huang)(huang)(huang)芩(qin)(qin)素-7-O-D葡萄(tao)糖醛酸2.5×10(-4)mol/l,1.0×10(-4)mol/l,對FeC12-維生素C-ADP混合(he)物(wu)誘(you)導的大鼠(shu)(shu)肝勻漿脂質過氧(yang)化(hua)有抑(yi)制(zhi)(zhi)作(zuo)用(yong),使肝MDA的形成顯(xian)著下降(jiang),對NADPH一ADP引起的脂質過氧(yang)化(hua)也抑(yi)制(zhi)(zhi)。
抗癌:黃芩(qin)醚提物對小(xiao)鼠(shu)(shu)白血病L1210細胞有細胞毒作用,半(ban)數(shu)有效(xiao)量為(wei)10.4mg/ml,黃芩(qin)黃酮Ⅱ對小(xiao)鼠(shu)(shu)L1210細胞的半(ban)數(shu)有效(xiao)量為(wei)1.5μg/ml,黃芩(qin)甙、黃芩(qin)素及(ji)漢黃芩(qin)素對L1210作用不顯(xian)著。
其它作(zuo)(zuo)用(yong):黃(huang)(huang)芩(qin)素10,20mg/kg靜脈注射,對(dui)麻醉犬有(you)(you)(you)利(li)尿(niao)作(zuo)(zuo)用(yong)。黃(huang)(huang)芩(qin)煎劑4g/kg灌胃,對(dui)大鼠半乳糖性白內(nei)障有(you)(you)(you)防治(zhi)作(zuo)(zuo)用(yong),可(ke)延緩白內(nei)障的(de)(de)形成。黃(huang)(huang)芩(qin)甙(dai)(dai)對(dui)大鼠晶體(ti)醛糖還原酶(mei)有(you)(you)(you)抑(yi)(yi)(yi)制(zhi)作(zuo)(zuo)用(yong),其ID50為(wei)1.81×10(-3)mg/ml。黃(huang)(huang)芩(qin)甙(dai)(dai)150mg/kg灌胃,對(dui)鏈黑霉(mei)素引(yin)起的(de)(de)糖尿(niao)病(bing)大鼠血糖水(shui)平無(wu)明顯下降,但紅細胞山梨醇(chun)含量于(yu)治(zhi)療后顯著降低,提示在(zai)動(dong)物(wu)體(ti)內(nei)也(ye)有(you)(you)(you)抑(yi)(yi)(yi)制(zhi)醛糖酶(mei)的(de)(de)作(zuo)(zuo)用(yong),有(you)(you)(you)可(ke)能用(yong)于(yu)糖尿(niao)病(bing)性并發癥的(de)(de)防治(zhi)。黃(huang)(huang)芩(qin)甙(dai)(dai)、黃(huang)(huang)芩(qin)素及漢黃(huang)(huang)芩(qin)素50-125μg/ml對(dui)小(xiao)鼠肝(gan)唾(tuo)液酸(suan)酶(mei)有(you)(you)(you)抑(yi)(yi)(yi)制(zhi)作(zuo)(zuo)用(yong)。黃(huang)(huang)芩(qin)甙(dai)(dai)100mg/kg,葡(pu)萄糖醛酸(suan)43mg/kg皮(pi)下注射均可(ke)對(dui)抗士的(de)(de)寧引(yin)起的(de)(de)小(xiao)鼠死亡,而(er)甙(dai)(dai)元黃(huang)(huang)芩(qin)素無(wu)效,認為(wei)黃(huang)(huang)芩(qin)甙(dai)(dai)水(shui)解后的(de)(de)葡(pu)萄糖醛酸(suan)起的(de)(de)解毒作(zuo)(zuo)用(yong)。黃(huang)(huang)芩(qin)對(dui)PGs的(de)(de)代謝有(you)(you)(you)較廣泛的(de)(de)影響(xiang),水(shui)提物(wu)對(dui)PGs的(de)(de)生物(wu)合成有(you)(you)(you)抑(yi)(yi)(yi)制(zhi)作(zuo)(zuo)用(yong)。
李時(shi)(shi)珍(zhen)(zhen)生于(yu)明朝嘉(jia)靖(jing)年間,自幼聰(cong)明伶(ling)俐,好學(xue)上進,小(xiao)小(xiao)年紀(ji)就立志(zhi)考取(qu)功名。光耀(yao)門庭。可是天有不測風云,在李時(shi)(shi)珍(zhen)(zhen)十、六歲時(shi)(shi),他突患急病,咳嗽不止(zhi),并且(qie)久冶不愈(yu)。隨著病情加劇,他每日吐(tu)痰(tan)碗余,煩、渴引飲,骨蒸勞(lao)熱(re),六脈浮洪,雖(sui)服用柴胡、麥冬、荊芥、竹瀝(li)等解表退熱(re)、潤肺清心(xin)、清熱(re)化痰(tan)之(zhi)劑卻并無效果(guo)。方圓百里的名醫都束手無策,認(ren)為其(qi)已無藥(yao)可救。眼看小(xiao)時(shi)(shi)珍(zhen)(zhen)生命(ming)危在旦(dan)夕。
正在李時(shi)珍(zhen)的父母悲傷絕望之際,村子里來了(le)一位從遠方云(yun)游(you)到(dao)此的道士(shi),這(zhe)位道人白發長髯,頗(po)有一種仙(xian)風道骨的味(wei)道。聞言道人專治(zhi)疑難(nan)雜癥(zheng),小時(shi)珍(zhen)的父母急忙把道人請到(dao)家(jia)中給他看病。道士(shi)給小時(shi)珍(zhen)號了(le)脈(mo)象后,捋捋長髯說(shuo):“不(bu)(bu)妨,不(bu)(bu)妨,此病只需服用黃(huang)(huang)芩30克,加水兩盅(zhong),煎至一盅(zhong),服用半(ban)月(yue)即可痊愈。“時(shi)珍(zhen)的父母半(ban)信(xin)半(ban)疑地按方煎藥。奇跡出(chu)現了(le)。半(ban)月(yue)之后,小時(shi)珍(zhen)身(shen)熱全退(tui),痰多(duo)咳嗽的癥(zheng)狀也(ye)消失(shi)了(le),身(shen)體逐(zhu)漸恢(hui)復健康。一味(wei)黃(huang)(huang)芩居然起(qi)到(dao)了(le)立竿見影的治(zhi)療效果。
李(li)時珍深(shen)感中(zhong)國醫學的(de)神奇(qi),更對這(zhe)(zhe)位身懷(huai)絕技(ji)的(de)道士欽佩不已,從此,便跟隨道人刻苦鉆(zhan)研醫學,讀遍(bian)歷代(dai)醫書,踏遍(bian)高山大川(chuan)。功(gong)夫不負(fu)有心人,李(li)時珍終于在醫學上取得(de)了(le)巨(ju)大的(de)成就,成為(wei)醫林(lin)一(yi)代(dai)宗師。在他(ta)編著的(de)《本草綱目》中(zhong),李(li)時珍對救了(le)他(ta)性命(ming)的(de)黃芩這(zhe)(zhe)味中(zhong)藥推崇(chong)備加,稱之為(wei)“藥中(zhong)肯綮,如鼓應桴,醫中(zhong)之妙,有如此哉!