黃(huang)芩(拉丁學(xue)名:Scutellaria baicalensis Georgi),別(bie)名山茶根、土(tu)金茶根,是唇形(xing)科黃(huang)芩屬多年生草本植物;肉質(zhi)(zhi)根莖(jing)肥(fei)厚(hou),葉堅(jian)紙質(zhi)(zhi),披針形(xing)至線(xian)狀(zhuang)披針形(xing),總狀(zhuang)花(hua)序在(zai)莖(jing)及(ji)枝上頂(ding)生,花(hua)冠(guan)紫、紫紅至藍色,花(hua)絲扁平,花(hua)柱細長,花(hua)盤環狀(zhuang),子房(fang)褐色,小(xiao)堅(jian)果(guo)卵球形(xing),花(hua)果(guo)期7~9月。
黃芩生于向(xiang)陽草坡(po)地、休荒地上,海拔(ba)60~1300(1700~2000)米。產于黑龍(long)江(jiang),遼寧,內蒙古(gu)(gu),河北,河南(nan),甘(gan)肅,陜(shan)西,山(shan)西,山(shan)東,四川等地,中國北方多數省區都可種植。俄(e)羅(luo)(luo)斯(si)東西伯利亞,蒙古(gu)(gu),朝鮮,日本均有分布。模式標本采自俄(e)羅(luo)(luo)斯(si)。
黃芩的根入藥(yao),味苦(ku)、性(xing)寒,有(you)清熱燥濕、瀉(xie)火解(jie)毒、止(zhi)血(xue)、安(an)胎(tai)等功效。主治溫熱病、上呼(hu)吸道感染、肺熱咳嗽(sou)、濕熱黃膽、肺炎、痢疾、咳血(xue)、目赤、胎(tai)動(dong)不(bu)(bu)安(an)、高(gao)血(xue)壓(ya)、癰腫癤瘡(chuang)等癥。黃芩的臨床抗菌(jun)性(xing)比黃連好,而且不(bu)(bu)產生抗藥(yao)性(xing)。
生(sheng)于(yu)向陽草坡地、休荒地上(shang),海拔60~1300(1700~2000)米(mi)。
黃芩野生(sheng)于山頂、山坡(po)、林緣、路旁等向(xiang)陽(yang)較(jiao)干燥的地(di)方。喜溫(wen)暖,耐(nai)(nai)嚴寒,成(cheng)年(nian)植株(zhu)地(di)下部分在(zai)-35℃低溫(wen)下仍能安全(quan)越冬,35℃高溫(wen)不致枯死,但不能經受40℃以(yi)上連續高溫(wen)天(tian)氣(qi)。耐(nai)(nai)旱怕(pa)澇,地(di)內(nei)積水或(huo)雨水過多,生(sheng)長不良,重者爛根(gen)死亡(wang)。排水不良的土地(di)不宜種植。土壤以(yi)壤土和沙質壤士(shi),酸堿(jian)度(du)以(yi)中性和微堿(jian)性為好,忌連作。
黃芩主(zhu)要分布在山(shan)東、陜西、山(shan)西、甘(gan)肅四大產區(qu),其中(zhong)集中(zhong)在山(shan)西絳縣(xian)南凡鎮(zhen)(zhen)(zhen)(zhen)、運城(cheng)市(shi)夏(xia)縣(xian)瑤(yao)峰鎮(zhen)(zhen)(zhen)(zhen)、新絳縣(xian)萬安鎮(zhen)(zhen)(zhen)(zhen)、萬榮縣(xian)、聞喜(xi)縣(xian)薛(xue)店鎮(zhen)(zhen)(zhen)(zhen)等地;陜西商(shang)(shang)洛(luo)、渭(wei)南臨渭(wei)區(qu)橋南鎮(zhen)(zhen)(zhen)(zhen)、商(shang)(shang)州市(shi)商(shang)(shang)州區(qu)孝義鎮(zhen)(zhen)(zhen)(zhen)、洛(luo)南縣(xian)景村鎮(zhen)(zhen)(zhen)(zhen)、丹(dan)鳳(feng)縣(xian)棣(di)花鎮(zhen)(zhen)(zhen)(zhen)、商(shang)(shang)洛(luo)市(shi)夜(ye)村鎮(zhen)(zhen)(zhen)(zhen)、丹(dan)鳳(feng)縣(xian)商(shang)(shang)鎮(zhen)(zhen)(zhen)(zhen)等地;山(shan)東沂(yi)蒙(meng)山(shan)區(qu)、莒縣(xian)庫(ku)山(shan)鄉、萊蕪(wu)市(shi)茶葉口(kou)鎮(zhen)(zhen)(zhen)(zhen)、富官莊鄉等地;甘(gan)肅主(zhu)產隴西、渭(wei)源、漳縣(xian),次產岷(min)縣(xian)、宕昌、河(he)西等地。
黃芩主(zhu)要分布中國內蒙中東部(bu)(bu)和東北(bei)三省大部(bu)(bu),河北(bei)承德(de),內蒙古赤峰等幾個最具規模(mo)的主(zhu)產區,是中國北(bei)方野生中藥材的主(zhu)要產地之一(yi)。
多年生草本;根莖肥厚,肉質,徑達(da)2厘(li)米,伸長(chang)而分枝(zhi)。莖基部伏地,上升,高30~120厘(li)米,基部徑2.5-3毫米,鈍四棱形,具細條紋,近無(wu)毛(mao)或(huo)被(bei)上曲至開展的(de)微柔毛(mao),綠色或(huo)帶(dai)紫色,自(zi)基部多分枝(zhi)。
葉堅紙質(zhi),披(pi)針(zhen)形(xing)至(zhi)線狀披(pi)針(zhen)形(xing),長(chang)(chang)1.5~4.5厘米,寬0.5~1.2厘米,頂端鈍,基部(bu)圓形(xing),全(quan)緣,上(shang)面暗(an)綠色,無(wu)毛或(huo)疏被(bei)貼生(sheng)至(zhi)開展的微柔毛,下(xia)面色較淡,無(wu)毛或(huo)沿中(zhong)(zhong)脈(mo)疏被(bei)微柔毛,密被(bei)下(xia)陷(xian)(xian)的腺點(dian),側脈(mo)4對,與中(zhong)(zhong)脈(mo)上(shang)面下(xia)陷(xian)(xian)下(xia)面凸出;葉柄短,長(chang)(chang)2毫米,腹(fu)凹(ao)背凸,被(bei)微柔毛。
花(hua)(hua)(hua)序(xu)在(zai)莖(jing)及枝(zhi)上(shang)頂(ding)生(sheng),總狀(zhuang),長(chang)7~15厘(li)(li)米(mi)(mi),常再于莖(jing)頂(ding)聚成圓錐(zhui)花(hua)(hua)(hua)序(xu);花(hua)(hua)(hua)梗(geng)長(chang)3毫(hao)(hao)米(mi)(mi),與序(xu)軸均被(bei)(bei)微柔(rou)毛(mao)(mao)(mao)(mao);苞片(pian)(pian)下(xia)部(bu)(bu)者似葉,上(shang)部(bu)(bu)者遠較(jiao)小(xiao),卵圓狀(zhuang)披針(zhen)形(xing)至披針(zhen)形(xing),長(chang)4~11毫(hao)(hao)米(mi)(mi),近(jin)于無(wu)毛(mao)(mao)(mao)(mao)。花(hua)(hua)(hua)萼(e)開花(hua)(hua)(hua)時長(chang)4毫(hao)(hao)米(mi)(mi),盾片(pian)(pian)高(gao)1.5毫(hao)(hao)米(mi)(mi),外面密被(bei)(bei)微柔(rou)毛(mao)(mao)(mao)(mao),萼(e)緣(yuan)被(bei)(bei)疏(shu)柔(rou)毛(mao)(mao)(mao)(mao),內(nei)(nei)面無(wu)毛(mao)(mao)(mao)(mao),果時花(hua)(hua)(hua)萼(e)長(chang)5毫(hao)(hao)米(mi)(mi),有高(gao)4毫(hao)(hao)米(mi)(mi)的(de)盾片(pian)(pian)。花(hua)(hua)(hua)冠(guan)紫、紫紅至藍色(se),長(chang)2.3~3厘(li)(li)米(mi)(mi),外面密被(bei)(bei)具腺短柔(rou)毛(mao)(mao)(mao)(mao),內(nei)(nei)面在(zai)囊狀(zhuang)膨大(da)(da)處被(bei)(bei)短柔(rou)毛(mao)(mao)(mao)(mao);冠(guan)筒近(jin)基部(bu)(bu)明顯膝曲(qu),中部(bu)(bu)徑1.5毫(hao)(hao)米(mi)(mi),至喉部(bu)(bu)寬達6毫(hao)(hao)米(mi)(mi);冠(guan)檐2唇(chun)形(xing),上(shang)唇(chun)盔狀(zhuang),先端微缺,下(xia)唇(chun)中裂片(pian)(pian)三角狀(zhuang)卵圓形(xing),寬7.5毫(hao)(hao)米(mi)(mi),兩側(ce)裂片(pian)(pian)向上(shang)唇(chun)靠合(he)。雄(xiong)蕊4,稍(shao)露出,前(qian)對較(jiao)長(chang),具半(ban)藥,退化(hua)半(ban)藥不明顯,后對較(jiao)短,具全藥,藥室裂口具白色(se)髯毛(mao)(mao)(mao)(mao),背部(bu)(bu)具泡狀(zhuang)毛(mao)(mao)(mao)(mao);花(hua)(hua)(hua)絲扁平,中部(bu)(bu)以下(xia)前(qian)對在(zai)內(nei)(nei)側(ce)后對在(zai)兩側(ce)被(bei)(bei)小(xiao)疏(shu)柔(rou)毛(mao)(mao)(mao)(mao)。花(hua)(hua)(hua)柱細長(chang),先端銳尖(jian),微裂。花(hua)(hua)(hua)盤環狀(zhuang),高(gao)0.75毫(hao)(hao)米(mi)(mi),前(qian)方稍(shao)增大(da)(da),后方延(yan)伸成極短子房柄。子房褐色(se),無(wu)毛(mao)(mao)(mao)(mao)。
小堅(jian)果(guo)卵球形,高1.5毫(hao)米,徑(jing)1毫(hao)米,黑褐色,具瘤,腹面近基部具果(guo)臍。花期7-8月,果(guo)期8-9月。
根(gen)的生長:黃(huang)芩(qin)(qin)為直(zhi)根(gen)系,主根(gen)在前三年生長正常,其(qi)主根(gen)長度、粗(cu)度、鮮(xian)重和干重均(jun)逐年增加,主根(gen)中黃(huang)芩(qin)(qin)苷(gan)含(han)量(liang)較(jiao)高。第四(si)年以后,生長速度開(kai)始變慢,部分主根(gen)開(kai)始出(chu)現(xian)枯心,以后逐年加重,八年生的家重黃(huang)芩(qin)(qin)幾乎所(suo)有主根(gen)及較(jiao)粗(cu)的側根(gen)全部枯心,而且黃(huang)芩(qin)(qin)苷(gan)的含(han)量(liang)也大幅度降低。
莖(jing)(jing)、葉(xie)生(sheng)長:出(chu)苗后,主莖(jing)(jing)逐漸長高,葉(xie)數逐漸增加,隨后形(xing)成分枝并現(xian)蕾、開花(hua)、結實(shi)。5~6月(yue)為(wei)莖(jing)(jing)葉(xie)生(sheng)長期,一年生(sheng)黃(huang)芩主莖(jing)(jing)約(yue)可(ke)長出(chu)30對(dui)葉(xie),其中前五對(dui)葉(xie)每4~6天長出(chu)1對(dui),其后葉(xie)片每2~3天長出(chu)1對(dui)。
開(kai)花結果:一年生植株一般(ban)出苗后(hou)2個月開(kai)始(shi)(shi)現(xian)蕾,二年生及其(qi)以后(hou)的黃(huang)芩,多于(yu)返青出苗后(hou)70~80天開(kai)始(shi)(shi)現(xian)蕾,現(xian)蕾后(hou)10天左右開(kai)始(shi)(shi)開(kai)花,40天左右果實開(kai)始(shi)(shi)成(cheng)熟,如環境條件適宜黃(huang)芩開(kai)花結實可持續(xu)到(dao)霜枯期(qi)。
采取種子直播時,當幼苗(miao)長到4厘米高時要間去過密和瘦弱(ruo)的小苗(miao),按株距10厘米定(ding)苗(miao)。育苗(miao)地不必(bi)間苗(miao)。
幼(you)(you)苗出土后,應及時松(song)土除(chu)草,并結合松(song)土向幼(you)(you)苗四周適當培土,保持疏松(song)、無雜草,一年需(xu)要除(chu)草3-4次。
苗高(gao)10-15厘米時,追(zhui)肥1次,施(shi)用量(liang)為每(mei)畝(mu)用人畜糞水(shui)1500-2000千(qian)克(ke)(ke)(ke)。6月底-7月初,每(mei)畝(mu)追(zhui)施(shi)過磷(lin)酸鈣(gai)20千(qian)克(ke)(ke)(ke)、尿素5千(qian)克(ke)(ke)(ke),行間(jian)開溝施(shi)下(xia),覆(fu)土后(hou)澆水(shui)。次年收獲的待植株枯萎后(hou),于行間(jian)開溝每(mei)畝(mu)追(zhui)施(shi)腐熟廄(jiu)肥2000千(qian)克(ke)(ke)(ke)、過磷(lin)酸鈣(gai)20千(qian)克(ke)(ke)(ke)、尿素5千(qian)克(ke)(ke)(ke)、草木灰150千(qian)克(ke)(ke)(ke),然后(hou)覆(fu)土蓋平。
黃芩耐旱怕澇(lao),雨季需注意排水(shui),田間不(bu)可(ke)(ke)積(ji)水(shui),否(fou)則易爛根(gen)。遇嚴(yan)重干旱時或追(zhui)肥(fei)后,可(ke)(ke)適當(dang)澆水(shui)。
在(zai)抽出花(hua)序前,將花(hua)梗減掉,可減少養分消耗,促(cu)使(shi)根系生長,提高產量。
種子繁殖:
⑴直播法
種(zhong)子繁殖(zhi)以直播(bo)(bo)為主,直播(bo)(bo)黃芩根(gen)系直,根(gen)叉少,商品外觀品質好(hao),同時省工。
直(zhi)播(bo)多于春(chun)季進行,一(yi)般在(zai)(zai)地(di)下5厘米地(di)溫穩定在(zai)(zai)12℃-15℃時(shi)播(bo)種(zhong),北(bei)方地(di)區多在(zai)(zai)4月上中旬前后。
⑵育苗移栽法
育(yu)苗(miao)(miao)移栽法可(ke)節省種子,延長生長時(shi)間,利于(yu)確保全苗(miao)(miao),但較(jiao)為費工,同時(shi)移栽黃芩主根較(jiao)短(duan),根叉較(jiao)多(duo),商(shang)品外觀品質差,一(yi)般在(zai)種子昂貴或者旱地(di)缺水直(zhi)播難以出苗(miao)(miao)保苗(miao)(miao)時(shi)采用(yong)。
扦(qian)插(cha)繁殖(zhi):扦(qian)插(cha)雖可繁殖(zhi),但生產中很少采用。扦(qian)插(cha)成(cheng)(cheng)敗的關鍵在于扦(qian)插(cha)季節和取條部分(fen)(fen)。扦(qian)插(cha)時間以(yi)春季5-6月份扦(qian)插(cha)成(cheng)(cheng)活(huo)率高。插(cha)條應選莖(jing)尖半木質化的幼嫩部分(fen)(fen),扦(qian)插(cha)成(cheng)(cheng)活(huo)率可達90%以(yi)上。
分(fen)根(gen)繁殖(zhi):即(ji)挖取洞未(wei)萌發(fa)的3年生(sheng)黃芩根(gen)莖,切取主(zhu)根(gen)留供藥用,然(ran)后(hou)根(gen)據根(gen)莖生(sheng)長的自然(ran)形狀分(fen)切成若干塊,每塊有芽眼2-3個即(ji)可栽種。分(fen)根(gen)繁殖(zhi)雖然(ran)生(sheng)長快,但繁殖(zhi)系數(shu)太低,生(sheng)產中很少(shao)采用。
病害有葉枯病,可清(qing)潔田園,發端正初期噴(pen)灑(sa)1:1:200波爾多液,或用(yong)50%多菌靈1000倍液防(fang)治。
根腐病,注意排水(shui),實行輪作;及早撥出(chu)病株燒毀,病株處土(tu)壤用石灰消毒。
蟲(chong)(chong)害有黃芩舞蛾,可用(yong)90%敵(di)百蟲(chong)(chong)防治。
付方
性味:苦,寒。
①《本經(jing)》:味苦,平。
②《別(bie)錄》:大寒,無毒。
③《藥(yao)性論》:味(wei)苦(ku)甘。
歸經:入心、肺、膽(dan)、大腸經。
①《品匯精要》:行手太陰、陽明經。
②《綱目》:入手少陰、陽明,手足太陰、少陽六經。
③《雷公炮(pao)制藥性(xing)解》:入肺、大腸(chang)、膀胱、膽四經(jing)。
瀉實火,除濕熱(re),止血(xue),安胎。治(zhi)壯熱(re)煩渴,肺熱(re)咳嗽,濕熱(re)瀉痢(li),黃疸,熱(re)淋,吐、衄、崩、漏,目赤腫痛(tong),胎動不安,癰腫疔瘡。
①《本經》:主諸熱黃疸,腸澼,泄(xie)利,逐水,下血閉,(治)惡瘡,疽蝕,火瘍。
②《別錄》:療痰熱(re),胃中熱(re),小(xiao)腹絞(jiao)痛,消谷,利小(xiao)腸(chang),女子血閉,淋(lin)露下血,小(xiao)兒腹痛。
③陶(tao)弘(hong)景:治奔豚(tun),臍(qi)下熱痛。
④《藥性論》:能治熱(re)毒,骨蒸,寒熱(re)往來,腸(chang)胃不利,破壅氣,治五淋,令人宣(xuan)暢,去關節煩悶(men),解(jie)熱(re)渴,治熱(re)腹中(zhong)疞痛,心腹堅脹。
⑤《日華子本草》:下氣,主(zhu)天行熱疾(ji),疔瘡(chuang),排膿(nong)。治乳(ru)癰,發背(bei)。
⑥《珍珠(zhu)囊》:除陽有余,涼心去(qu)熱(re),通(tong)寒格。
⑦李杲(gao):治發熱(re)口苦(ku)。
⑧《滇南(nan)本草》:上行(xing)瀉(xie)肺火(huo),下行(xing)瀉(xie)膀胱火(huo),(治)男子五淋(lin),女子暴崩,調(diao)經清熱,胎有火(huo)熱不安(an),清胎熱,除六經實火(huo)實熱。
⑨《綱目》:治風熱濕熱頭疼(teng),奔豚熱痛,火(huo)咳,肺痿喉腥,諸失(shi)血。
⑩《本草正》:枯者清(qing)上(shang)焦之(zhi)(zhi)火,消(xiao)痰利氣,定喘嗽(sou),止失血,退往(wang)來寒(han)熱(re)(re)(re)(re)(re),風熱(re)(re)(re)(re)(re)濕熱(re)(re)(re)(re)(re),頭痛(tong),解瘟疫,清(qing)咽,療肺痿肺癰,乳癰發背,尤(you)祛肌表之(zhi)(zhi)熱(re)(re)(re)(re)(re),故(gu)治斑疹、鼠瘺,瘡瘍、赤(chi)眼(yan);實者涼(liang)下焦之(zhi)(zhi)熱(re)(re)(re)(re)(re),能除赤(chi)痢,熱(re)(re)(re)(re)(re)蓄膀胱,五淋(lin)澀痛(tong),大(da)腸閉結,便血、漏血。
⑾《科(ke)學(xue)的(de)民間藥(yao)草》:外洗(xi)創(chuang)口,有(you)防腐作用(yong)。
內服:煎湯(tang),1~3錢;或入丸、散。外用(yong):煎水(shui)洗或研(yan)末撤。
黃(huang)(huang)(huang)(huang)(huang)芩(qin)根含黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)類化(hua)合(he)物:黃(huang)(huang)(huang)(huang)(huang)芩(qin)素(su)(su)(su)(su)(baicalein),黃(huang)(huang)(huang)(huang)(huang)芩(qin)新素(su)(su)(su)(su)(neobaicalein),即黃(huang)(huang)(huang)(huang)(huang)芩(qin)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)Ⅱ(skullcapflavoneⅡ),黃(huang)(huang)(huang)(huang)(huang)芩(qin)甙(dai)(dai)(dai)(baicalin),漢黃(huang)(huang)(huang)(huang)(huang)芩(qin)素(su)(su)(su)(su)(wogonin),漢黃(huang)(huang)(huang)(huang)(huang)芩(qin)甙(dai)(dai)(dai)(wogono-side),木蝴(hu)蝶(die)素(su)(su)(su)(su)A(oroxylin,oroxylin A),7-甲(jia)(jia)(jia)(jia)(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)芩(qin)素(su)(su)(su)(su)(7-methoxbaic alein),黃(huang)(huang)(huang)(huang)(huang)芩(qin)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(skullcapflavone)Ⅰ,二(er)氫(qing)木蝴(hu)蝶(die)素(su)(su)(su)(su)A(dihydrooroxylin A),白(bai)楊素(su)(su)(su)(su)(chrysin),2,5,8-三(san)(san)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)-7-甲(jia)(jia)(jia)(jia)(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(2,5,8-trihydroxy-7-methoxy-flavone),2,5,8-三(san)(san)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)-6,7-二(er)甲(jia)(jia)(jia)(jia)(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(2,5,8-trihydroxy-6,7-dimethoxyflavone),4,5,7-三(san)(san)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)-6-甲(jia)(jia)(jia)(jia)(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)烷(wan)酮(tong)(tong)(tong)(tong)(tong)(4,5,7-trhydroxy-6-methoxyflavanone),2,3,5,6,7-五羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)烷(wan)酮(tong)(tong)(tong)(tong)(tong)(2,3,5,6,7-pentahydroxyflavanone),漢黃(huang)(huang)(huang)(huang)(huang)芩(qin)素(su)(su)(su)(su)-5-β-D-葡(pu)萄(tao)糖(tang)(tang)(tang)(tang)甙(dai)(dai)(dai)(wogonin-5-β-D-glucoside),2-(3-羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)-4-甲(jia)(jia)(jia)(jia)(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)苯基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji))-乙基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)-1-O-α-L-鼠李(li)糖(tang)(tang)(tang)(tang)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(1→3)-β-D(4-阿魏酰基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji))-葡(pu)萄(tao)糖(tang)(tang)(tang)(tang)〔2-(3-hydroxy-4-methoxyphenyl)ethyl-1-O-α-L-rhamnosyl(1→3)-β-D-(4-feruloyl)glucoside〕,白(bai)楊素(su)(su)(su)(su)-6-C-α-L-阿拉伯(bo)糖(tang)(tang)(tang)(tang)甙(dai)(dai)(dai)(chrysin-6-C-β-D-glucoside-8-C-β-L-arabinoside),白(bai)楊素(su)(su)(su)(su)-6-C-α-L-阿拉伯(bo)糖(tang)(tang)(tang)(tang)甙(dai)(dai)(dai)-8-C-β-D-葡(pu)萄(tao)糖(tang)(tang)(tang)(tang)甙(dai)(dai)(dai)(chrysin-6-C-α-L-arabi-noside-8-C-β-D-glucoside),(2S)-2,5,6,7-四(si)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)烷(wan)酮(tong)(tong)(tong)(tong)(tong)〔(2S)-25,6,7-terahydroxyflavanone〕,5,7,2,6-四(si)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5,7,2,6-tetrahydroxyflavone),5,8-二(er)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)-6,7-二(er)甲(jia)(jia)(jia)(jia)(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5,8-dihydroxy-6,7-drimethoxyflavone),5,7,4-三(san)(san)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)-8-甲(jia)(jia)(jia)(jia)(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5,7,4-trihydroxy-8-methoxyflavone),木蝴(hu)蝶(die)素(su)(su)(su)(su)A-7-O-葡(pu)萄(tao)糖(tang)(tang)(tang)(tang)醛酸甙(dai)(dai)(dai)(oroxylinA-7-O-glucuronide),5,7,2-三(san)(san)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)甲(jia)(jia)(jia)(jia)(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5,7,2-trihyroxy-6-methoxyflavone),5,2-二(er)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)-6,7,8-三(san)(san)甲(jia)(jia)(jia)(jia)(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5,2-dihydroxy-6,7,8-trimethoxyfla-vone),5-閎基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)-7,8-二(er)甲(jia)(jia)(jia)(jia)(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5-hydroxy-7,8-dimethoxy-flavone),去甲(jia)(jia)(jia)(jia)(jia)漢黃(huang)(huang)(huang)(huang)(huang)芩(qin)素(su)(su)(su)(su)(norwogonin),二(er)氫(qing)黃(huang)(huang)(huang)(huang)(huang)芩(qin)素(su)(su)(su)(su)(dihydro-baicalin),5,7,2-三(san)(san)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5,7,2-trihydroxyflavone),5,7,2-三(san)(san)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)-8,6-二(er)甲(jia)(jia)(jia)(jia)(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5,7,2-trihydroxy-8,6-dimethoxyflavone),5,7,2,5-四(si)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)-8,6-二(er)甲(jia)(jia)(jia)(jia)(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)即粘毛(mao)黃(huang)(huang)(huang)(huang)(huang)芩(qin)素(su)(su)(su)(su)Ⅲ(5,7,2,5-tetrahydroxy-8,6-dimethoxyflavone,vis-ciduiin Ⅲ,5,2,5-三(san)(san)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)三(san)(san)甲(jia)(jia)(jia)(jia)(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5,2,5-trihy-droxy-6,7,8-trimethoxyflavone),黃(huang)(huang)(huang)(huang)(huang)芩(qin)素(su)(su)(su)(su)-7-O-β-D-吡喃葡(pu)萄(tao)糖(tang)(tang)(tang)(tang)甙(dai)(dai)(dai)(baicalein-7-O-β-D-glucopyranoside),5,7,2-三(san)(san)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)-8-甲(jia)(jia)(jia)(jia)(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5,7,2-trhiyroxy-8-methoxyflavone),5,7,2,3-四(si)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5,7,2,3-trihydroxy-6-methoxyflavone),5,7,2,3-四(si)閎基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5,7,2,3-tetrahydroxyflavone),3,5,7,2,5,6-五羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(3,5,7,2,5,6-pentahydroxyflavone)即粘毛(mao)黃(huang)(huang)(huang)(huang)(huang)芩(qin)素(su)(su)(su)(su)Ⅰ(viscidulin Ⅰ),(2S)-7,2,6-三(san)(san)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)-5-甲(jia)(jia)(jia)(jia)(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)烷(wan)酮(tong)(tong)(tong)(tong)(tong)〔(2S)-7,2,6-trihydroxy-5-methoxyflavanone〕,2,6,2,4-四(si)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)-6-甲(jia)(jia)(jia)(jia)(jia)氧(yang)(yang)(yang)(yang)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)查爾酮(tong)(tong)(tong)(tong)(tong)(2,6,2,4-tetrahydroxy-6-methoxychalcone),5,7,2,5-四(si)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)(ji)黃(huang)(huang)(huang)(huang)(huang)酮(tong)(tong)(tong)(tong)(tong)(5,7,2,5-tetrahydroxyflavone),左旋圣草(cao)素(su)(su)(su)(su)(eriodictyol),半枝蓮種(zhong)素(su)(su)(su)(su)(rivularin)及粘毛(mao)黃(huang)(huang)(huang)(huang)(huang)芩(qin)素(su)(su)(su)(su)Ⅲ-2-O-β-D-吡喃葡(pu)萄(tao)糖(tang)(tang)(tang)(tang)甙(dai)(dai)(dai)(viscidulin Ⅲ-2-O-β-D-glucoplyranoside)等。另(ling)外還含β-谷甾(zai)醇(chun)(β-sitosterol),菜油(you)甾(zai)醇(chun)(campesterol)及豆甾(zai)醇(chun)(stigmasterol)。
抗菌(jun)作(zuo)用(yong)(yong)(yong)(yong):黃(huang)芩(qin)煎(jian)(jian)劑(ji)100%濃(nong)度(du)(du)(du),平(ping)板(ban)法(fa)(fa)試(shi)驗,對痢(li)(li)疾(ji)桿(gan)菌(jun)、傷(shang)寒桿(gan)菌(jun)、副傷(shang)寒桿(gan)菌(jun)、霍(huo)亂(luan)(luan)弧(hu)菌(jun)、大腸桿(gan)菌(jun)、變形桿(gan)菌(jun)、綠膿(nong)桿(gan)菌(jun)、葡萄球菌(jun)、溶血性(xing)璉球菌(jun)(a,B)、肺炎(yan)雙(shuang)球菌(jun)、白喉(hou)桿(gan)菌(jun)等有抑(yi)(yi)制(zhi)作(zuo)用(yong)(yong)(yong)(yong)。黃(huang)芩(qin)煎(jian)(jian)劑(ji)試(shi)管法(fa)(fa)試(shi)驗1:1280濃(nong)度(du)(du)(du)可抑(yi)(yi)制(zhi)傷(shang)寒桿(gan)菌(jun)、溶血性(xing)鏈球菌(jun)a,1:640濃(nong)度(du)(du)(du)抑(yi)(yi)制(zhi)溶血性(xing)鏈球菌(jun)B,肺炎(yan)雙(shuang)球菌(jun)及福氏痢(li)(li)疾(ji)桿(gan)菌(jun)、人(ren)結核(he)桿(gan)菌(jun)H37,1:320濃(nong)度(du)(du)(du)可抑(yi)(yi)制(zhi)霍(huo)亂(luan)(luan)弧(hu)菌(jun)、志賀(he)氏痢(li)(li)疾(ji)桿(gan)菌(jun);1:80濃(nong)度(du)(du)(du)時(shi)宋內(nei)氏痢(li)(li)疾(ji)桿(gan)菌(jun)有抑(yi)(yi)制(zhi)作(zuo)用(yong)(yong)(yong)(yong)。黃(huang)芩(qin)醇(chun)浸液(ye)0.5g/ml或0。05g/ml,用(yong)(yong)(yong)(yong)瓊脂斜面培養,藥液(ye)與培養基(ji)1:1混(hun)合,對綠膿(nong)桿(gan)菌(jun)有抑(yi)(yi)制(zhi)作(zuo)用(yong)(yong)(yong)(yong)。黃(huang)芩(qin)醇(chun)浸液(ye)2g/ml濃(nong)度(du)(du)(du),平(ping)皿法(fa)(fa)試(shi)驗對大腸桿(gan)菌(jun)、桔草(cao)桿(gan)菌(jun)、金(jin)黃(huang)色葡萄球菌(jun)有抑(yi)(yi)制(zhi)作(zuo)用(yong)(yong)(yong)(yong)。黃(huang)芩(qin)煎(jian)(jian)劑(ji)、醇(chun)提劑(ji)1g/ml濃(nong)度(du)(du)(du),用(yong)(yong)(yong)(yong)平(ping)板(ban)法(fa)(fa)試(shi)驗時(shi)對腦膜炎(yan)球菌(jun)均有抑(yi)(yi)作(zuo)用(yong)(yong)(yong)(yong)。
抗真菌(jun)(jun)作用(yong):黃(huang)芩煎液(ye),試管斜面法試驗(yan)4%濃度(du)抑制(zhi)狗小(xiao)牙胞(bao)菌(jun)(jun)及(ji)堇色毛(mao)(mao)癬(xian)菌(jun)(jun),8%濃度(du)抑制(zhi)許(xu)蘭氏黃(huang)癬(xian)菌(jun)(jun),10%濃度(du)抑制(zhi)許(xu)蘭氏黃(huang)癬(xian)菌(jun)(jun)蒙(meng)古變種,15%濃度(du)抑制(zhi)共心性(xing)毛(mao)(mao)癬(xian)菌(jun)(jun)及(ji)鐵銹(xiu)色毛(mao)(mao)癬(xian)菌(jun)(jun)。黃(huang)芩水浸劑1:3濃度(du)在(zai)試管內對堇色毛(mao)(mao)癬(xian)菌(jun)(jun)、同心性(xing)毛(mao)(mao)癬(xian)菌(jun)(jun),許(xu)蘭氏黃(huang)癬(xian)菌(jun)(jun)、奧杜(du)盎(ang)氏小(xiao)芽胞(bao)癬(xian)菌(jun)(jun)、羊毛(mao)(mao)樣小(xiao)芽胞(bao)癬(xian)菌(jun)(jun)、紅色表(biao)皮癬(xian)菌(jun)(jun)、K、W、氏表(biao)皮癬(xian)菌(jun)(jun)、星(xing)形奴卡氏菌(jun)(jun)等(deng)有不同程度(du)抑菌(jun)(jun)作用(yong)。
抗病毒作用:黃芩煎劑(ji)25-100%濃(nong)度,體外試驗對乙型肝炎病毒DNA復制有抑制作用。
抗(kang)炎抗(kang)變態(tai)反應(ying):黃(huang)(huang)(huang)芩(qin)(qin)(qin)70%乙(yi)醇提取物200,500mg/kg灌(guan)胃(wei)黃(huang)(huang)(huang)芩(qin)(qin)(qin)素、黃(huang)(huang)(huang)芩(qin)(qin)(qin)甙、漢黃(huang)(huang)(huang)芩(qin)(qin)(qin)素50,100mg/kg灌(guan)胃(wei),可抑(yi)制(zhi)醋酸引起的(de)小鼠(shu)腹腔(qiang)滲出(chu)增(zeng)加,對(dui)(dui)48/80(一種化(hua)合(he)物名稱(cheng),Sigma生產)引起的(de)大鼠(shu)足腫(zhong)(zhong)也有(you)抑(yi)制(zhi)作用(yong),黃(huang)(huang)(huang)芩(qin)(qin)(qin)70%乙(yi)醇提取物500mg/kg灌(guan)胃(wei),黃(huang)(huang)(huang)芩(qin)(qin)(qin)素、黃(huang)(huang)(huang)芩(qin)(qin)(qin)甙及漢黃(huang)(huang)(huang)芩(qin)(qin)(qin)素100mg/kg灌(guan)胃(wei)對(dui)(dui)大鼠(shu)佐劑性關節炎有(you)抑(yi)制(zhi)作用(yong)。黃(huang)(huang)(huang)芩(qin)(qin)(qin)水提物100,200mg/kg灌(guan)胃(wei),對(dui)(dui)大鼠(shu)被動皮膚過敏(min)反應(ying)(PCA)有(you)抑(yi)制(zhi)作用(yong),但對(dui)(dui)氯化(hua)苦引起的(de)小鼠(shu)接觸皮炎(耳腫(zhong)(zhong)脹)無明顯影響。
對(dui)中樞神經系統的作用:黃(huang)芩(qin)(qin)煎(jian)劑4g/kg腹腔(qiang)注(zhu)射(she),對(dui)小鼠(shu)防御(yu)性條件(jian)反(fan)射(she)可使陽(yang)性反(fan)射(she)時延長,而對(dui)非(fei)條件(jian)反(fan)射(she)及(ji)分化無(wu)影響,說明黃(huang)芩(qin)(qin)可加強皮層抑(yi)制過程。黃(huang)芩(qin)(qin)煎(jian)劑2g/kg,對(dui)傷寒(han)(han)混合疫苗致(zhi)熱(re)家兔(tu)有(you)解熱(re)作用。但(dan)也(ye)有(you)報道黃(huang)芩(qin)(qin)水煎(jian)劑或酒浸劑5-9g/只灌胃,或2g/只im,均不能(neng)證明黃(huang)芩(qin)(qin)對(dui)傷寒(han)(han)疫苗致(zhi)熱(re)家兔(tu)有(you)解熱(re)作用。
對(dui)心(xin)血(xue)管(guan)的(de)作(zuo)用(yong)(yong):黃(huang)芩(qin)醇提液(ye)1g/kg靜脈(mo)注(zhu)(zhu)射(she),可使麻(ma)醉(zui)犬血(xue)壓(ya)下降(jiang)。黃(huang)芩(qin)煎劑0。06g/kg靜脈(mo)注(zhu)(zhu)射(she),對(dui)麻(ma)醉(zui)犬有(you)明顯降(jiang)壓(ya)作(zuo)用(yong)(yong)。黃(huang)芩(qin)素(su)(su)(su)20mg/kg靜脈(mo)注(zhu)(zhu)射(she),可使麻(ma)醉(zui)犬血(xue)壓(ya)下降(jiang)40-50%。黃(huang)芩(qin)浸劑灌(guan)胃/kg灌(guan)胃,3次(ci)/天,連續4周(zhou),使慢性腎性高血(xue)壓(ya)犬血(xue)壓(ya)下降(jiang),心(xin)率變慢。黃(huang)芩(qin)甙(dai)2×10(-4)mol/l,在豚鼠離體主動脈(mo)條、肺動脈(mo)條、氣管(guan)條及右心(xin)房(fang)均有(you)競爭性的(de)拮抗腎上(shang)腺素(su)(su)(su),去甲腎上(shang)腺素(su)(su)(su)及多巴胺引(yin)起的(de)收縮作(zuo)用(yong)(yong),也拮抗異丙腎上(shang)腺素(su)(su)(su)舒張氣管(guan)和(he)增加右心(xin)房(fang)自發頻(pin)率作(zuo)用(yong)(yong),提示(shi)黃(huang)芩(qin)甙(dai)對(dui)a,B1,B2受(shou)體均有(you)阻斷作(zuo)用(yong)(yong)。
抗血(xue)(xue)小板(ban)聚(ju)集(ji)及抗凝(ning):黃(huang)(huang)芩(qin)(qin)(qin)素(su)、漢(han)黃(huang)(huang)芩(qin)(qin)(qin)素(su)、千層紙素(su)A、黃(huang)(huang)芩(qin)(qin)(qin)黃(huang)(huang)酮Ⅱ及白楊素(su)(chrysin)于濃(nong)度(du)1。0mM時,均可(ke)抑(yi)制(zhi)(zhi)膠原(yuan)誘導的(de)大(da)鼠血(xue)(xue)小板(ban)聚(ju)集(ji),白楊素(su)對ADP誘導的(de)血(xue)(xue)小板(ban)聚(ju)集(ji)也(ye)有(you)抑(yi)制(zhi)(zhi)作用,黃(huang)(huang)芩(qin)(qin)(qin)素(su)及漢(han)黃(huang)(huang)芩(qin)(qin)(qin)素(su)對花生四烯酸誘導的(de)血(xue)(xue)小板(ban)聚(ju)集(ji)也(ye)有(you)抑(yi)制(zhi)(zhi)作用,黃(huang)(huang)芩(qin)(qin)(qin)素(su)及黃(huang)(huang)芩(qin)(qin)(qin)甙(dai)對凝(ning)血(xue)(xue)酶誘導的(de)纖(xian)(xian)維蛋(dan)白原(yuan)轉化為(wei)纖(xian)(xian)維蛋(dan)白也(ye)抑(yi)制(zhi)(zhi);黃(huang)(huang)芩(qin)(qin)(qin)素(su)及黃(huang)(huang)芩(qin)(qin)(qin)甙(dai)20,50mg/kg灌胃,對內(nei)毒素(su)誘導的(de)大(da)鼠彌漫性血(xue)(xue)管內(nei)凝(ning)血(xue)(xue),可(ke)以防止血(xue)(xue)小板(ban)及纖(xian)(xian)維蛋(dan)白原(yuan)含(han)量的(de)降低。
降(jiang)血(xue)脂(zhi):黃芩(qin)(qin)(qin)水浸液10%2ml/只灌胃,連續給藥7周,可(ke)(ke)使膽(dan)(dan)(dan)(dan)固醇(chun)喂飼的(de)(de)(de)(de)家兔血(xue)清(qing)膽(dan)(dan)(dan)(dan)固醇(chun)含量下降(jiang)。黃芩(qin)(qin)(qin)素(su)(su)、黃芩(qin)(qin)(qin)甙(dai)100mg/kg灌胃,可(ke)(ke)降(jiang)低實驗(yan)性高(gao)血(xue)脂(zhi)大鼠玉米油(you)(you)(you)-膽(dan)(dan)(dan)(dan)固醇(chun)-膽(dan)(dan)(dan)(dan)酸(suan)喂飼血(xue)清(qing)游離(li)(li)脂(zhi)肪酸(suan)、甘(gan)(gan)(gan)油(you)(you)(you)三酯(zhi)(zhi)及(ji)肝甘(gan)(gan)(gan)油(you)(you)(you)三酯(zhi)(zhi)的(de)(de)(de)(de)含量,黃芩(qin)(qin)(qin)黃酮Ⅱ100mg/kg灌胃,可(ke)(ke)降(jiang)低血(xue)清(qing)總膽(dan)(dan)(dan)(dan)固醇(chun)及(ji)肝甘(gan)(gan)(gan)油(you)(you)(you)三酯(zhi)(zhi)的(de)(de)(de)(de)含量,增加血(xue)清(qing)高(gao)密度(du)脂(zhi)蛋白(bai)-膽(dan)(dan)(dan)(dan)固醇(chun)(HDL-ch)的(de)(de)(de)(de)含量,漢黃芩(qin)(qin)(qin)素(su)(su)100mg/kg灌胃,可(ke)(ke)防止肝甘(gan)(gan)(gan)油(you)(you)(you)三酯(zhi)(zhi)的(de)(de)(de)(de)沉積并增加血(xue)清(qing)HDL-ch的(de)(de)(de)(de)含量。黃芩(qin)(qin)(qin)素(su)(su)、黃芩(qin)(qin)(qin)甙(dai)100mg/kg灌胃,對乙醇(chun)引(yin)起的(de)(de)(de)(de)高(gao)血(xue)脂(zhi)大鼠,可(ke)(ke)降(jiang)低肝總膽(dan)(dan)(dan)(dan)固醇(chun)、游離(li)(li)膽(dan)(dan)(dan)(dan)固醇(chun)及(ji)甘(gan)(gan)(gan)油(you)(you)(you)三酯(zhi)(zhi)含量,漢黃芩(qin)(qin)(qin)素(su)(su)能降(jiang)低血(xue)清(qing)甘(gan)(gan)(gan)油(you)(you)(you)三酯(zhi)(zhi)的(de)(de)(de)(de)水平,黃芩(qin)(qin)(qin)素(su)(su)能增加血(xue)清(qing)HDL-ch含量。
保肝(gan)(gan)、利膽、抗(kang)氧(yang)化(hua)(hua):黃(huang)芩(qin)(qin)(qin)甲醇(chun)提取物(wu)(wu)1000mg/kg腹腔注射,對異硫氰酸萘酯(ANIT)引起的大(da)鼠肝(gan)(gan)損害有(you)抑(yi)(yi)(yi)制作(zuo)(zuo)用(yong)(yong),可抑(yi)(yi)(yi)制血清(qing)膽紅素(su)的增(zeng)加。黃(huang)芩(qin)(qin)(qin)醇(chun)提物(wu)(wu)50,100mg/kg,黃(huang)芩(qin)(qin)(qin)甙50,100mg/kg灌胃(wei),對家兔(tu)有(you)利膽作(zuo)(zuo)用(yong)(yong)。漢(han)黃(huang)芩(qin)(qin)(qin)素(su)10(-4)-10(-6)mol/l濃度體外試驗,對大(da)鼠肝(gan)(gan)微粒體脂質(zhi)過(guo)(guo)氧(yang)化(hua)(hua)有(you)抑(yi)(yi)(yi)制作(zuo)(zuo)用(yong)(yong),使丙二醛(MDA)含(han)量下降。黃(huang)芩(qin)(qin)(qin)素(su)及黃(huang)芩(qin)(qin)(qin)甙2。5×10(-4)mol/l,1.0×10(-4)mol/l,漢(han)黃(huang)芩(qin)(qin)(qin)素(su)2.5×10(-4)mol/l,黃(huang)芩(qin)(qin)(qin)黃(huang)酮Ⅱ2。5×10(-4)mol/l,漢(han)黃(huang)芩(qin)(qin)(qin)素(su)-7-O-D葡萄糖醛酸2.5×10(-4)mol/l,1.0×10(-4)mol/l,對FeC12-維生(sheng)素(su)C-ADP混合(he)物(wu)(wu)誘導的大(da)鼠肝(gan)(gan)勻漿脂質(zhi)過(guo)(guo)氧(yang)化(hua)(hua)有(you)抑(yi)(yi)(yi)制作(zuo)(zuo)用(yong)(yong),使肝(gan)(gan)MDA的形成顯著下降,對NADPH一ADP引起的脂質(zhi)過(guo)(guo)氧(yang)化(hua)(hua)也抑(yi)(yi)(yi)制。
抗癌(ai):黃(huang)芩醚提物對小鼠白血病L1210細(xi)胞有細(xi)胞毒作(zuo)用,半(ban)數有效(xiao)(xiao)量(liang)(liang)為10.4mg/ml,黃(huang)芩黃(huang)酮Ⅱ對小鼠L1210細(xi)胞的半(ban)數有效(xiao)(xiao)量(liang)(liang)為1.5μg/ml,黃(huang)芩甙(dai)、黃(huang)芩素及漢黃(huang)芩素對L1210作(zuo)用不顯著(zhu)。
其它作(zuo)用(yong)(yong)(yong):黃(huang)(huang)芩(qin)(qin)(qin)素(su)(su)10,20mg/kg靜脈注(zhu)射,對(dui)(dui)麻醉犬(quan)有(you)(you)利尿作(zuo)用(yong)(yong)(yong)。黃(huang)(huang)芩(qin)(qin)(qin)煎劑(ji)4g/kg灌胃(wei)(wei),對(dui)(dui)大鼠(shu)(shu)半乳糖(tang)性白內障有(you)(you)防治作(zuo)用(yong)(yong)(yong),可延緩白內障的(de)(de)(de)(de)形(xing)成。黃(huang)(huang)芩(qin)(qin)(qin)甙對(dui)(dui)大鼠(shu)(shu)晶體醛(quan)糖(tang)還原酶有(you)(you)抑(yi)制(zhi)作(zuo)用(yong)(yong)(yong),其ID50為1.81×10(-3)mg/ml。黃(huang)(huang)芩(qin)(qin)(qin)甙150mg/kg灌胃(wei)(wei),對(dui)(dui)鏈黑霉素(su)(su)引(yin)起(qi)的(de)(de)(de)(de)糖(tang)尿病大鼠(shu)(shu)血糖(tang)水平無(wu)明(ming)顯下降,但紅(hong)細胞山梨(li)醇含量于(yu)治療后顯著降低,提示在(zai)動物體內也有(you)(you)抑(yi)制(zhi)醛(quan)糖(tang)酶的(de)(de)(de)(de)作(zuo)用(yong)(yong)(yong),有(you)(you)可能用(yong)(yong)(yong)于(yu)糖(tang)尿病性并發癥的(de)(de)(de)(de)防治。黃(huang)(huang)芩(qin)(qin)(qin)甙、黃(huang)(huang)芩(qin)(qin)(qin)素(su)(su)及漢(han)黃(huang)(huang)芩(qin)(qin)(qin)素(su)(su)50-125μg/ml對(dui)(dui)小鼠(shu)(shu)肝唾液酸酶有(you)(you)抑(yi)制(zhi)作(zuo)用(yong)(yong)(yong)。黃(huang)(huang)芩(qin)(qin)(qin)甙100mg/kg,葡萄(tao)糖(tang)醛(quan)酸43mg/kg皮下注(zhu)射均可對(dui)(dui)抗士的(de)(de)(de)(de)寧引(yin)起(qi)的(de)(de)(de)(de)小鼠(shu)(shu)死(si)亡(wang),而甙元黃(huang)(huang)芩(qin)(qin)(qin)素(su)(su)無(wu)效(xiao),認為黃(huang)(huang)芩(qin)(qin)(qin)甙水解(jie)(jie)后的(de)(de)(de)(de)葡萄(tao)糖(tang)醛(quan)酸起(qi)的(de)(de)(de)(de)解(jie)(jie)毒作(zuo)用(yong)(yong)(yong)。黃(huang)(huang)芩(qin)(qin)(qin)對(dui)(dui)PGs的(de)(de)(de)(de)代謝有(you)(you)較廣(guang)泛的(de)(de)(de)(de)影響,水提物對(dui)(dui)PGs的(de)(de)(de)(de)生物合成有(you)(you)抑(yi)制(zhi)作(zuo)用(yong)(yong)(yong)。
李時珍(zhen)(zhen)(zhen)生于明(ming)朝嘉靖年間(jian),自幼聰(cong)明(ming)伶俐,好學(xue)上進,小(xiao)小(xiao)年紀(ji)就立志考取功名(ming)。光耀門庭。可是天(tian)有不測風云,在李時珍(zhen)(zhen)(zhen)十、六歲時,他突患急病,咳嗽不止(zhi),并(bing)且久冶不愈(yu)。隨著病情加(jia)劇,他每日吐痰碗余,煩、渴引飲,骨(gu)蒸勞熱,六脈浮(fu)洪,雖服(fu)用柴胡、麥冬、荊芥、竹瀝等解表(biao)退(tui)熱、潤肺清心、清熱化痰之(zhi)劑卻并(bing)無效果。方(fang)圓百里的名(ming)醫(yi)都束手無策,認為其(qi)已(yi)無藥可救。眼看(kan)小(xiao)時珍(zhen)(zhen)(zhen)生命危在旦夕。
正在(zai)李時(shi)珍(zhen)的(de)父母悲傷絕望之際,村子里來(lai)了一(yi)(yi)位從(cong)遠方云游到此的(de)道(dao)(dao)(dao)士,這位道(dao)(dao)(dao)人(ren)白發長(chang)髯,頗(po)有(you)一(yi)(yi)種仙風道(dao)(dao)(dao)骨(gu)的(de)味道(dao)(dao)(dao)。聞言道(dao)(dao)(dao)人(ren)專(zhuan)治疑難雜癥(zheng),小(xiao)(xiao)時(shi)珍(zhen)的(de)父母急忙把(ba)道(dao)(dao)(dao)人(ren)請到家中給(gei)他看病。道(dao)(dao)(dao)士給(gei)小(xiao)(xiao)時(shi)珍(zhen)號了脈象(xiang)后,捋(lv)(lv)捋(lv)(lv)長(chang)髯說:“不妨,不妨,此病只需服(fu)用(yong)黃芩30克,加水兩(liang)盅(zhong),煎至一(yi)(yi)盅(zhong),服(fu)用(yong)半月即可痊愈。“時(shi)珍(zhen)的(de)父母半信半疑地按方煎藥。奇(qi)跡(ji)出現了。半月之后,小(xiao)(xiao)時(shi)珍(zhen)身熱(re)全(quan)退(tui),痰多(duo)咳嗽的(de)癥(zheng)狀也消失了,身體逐漸(jian)恢復健康。一(yi)(yi)味黃芩居然起(qi)到了立竿見(jian)影的(de)治療效果。
李(li)(li)時珍深感中國醫學(xue)的(de)(de)(de)(de)神(shen)奇,更對(dui)這(zhe)位身懷絕(jue)技(ji)的(de)(de)(de)(de)道士欽佩不已,從此,便跟隨道人刻苦鉆研醫學(xue),讀(du)遍(bian)歷代醫書,踏遍(bian)高(gao)山大川。功夫不負(fu)有心人,李(li)(li)時珍終于在醫學(xue)上取得了巨大的(de)(de)(de)(de)成(cheng)(cheng)就,成(cheng)(cheng)為醫林一代宗師。在他(ta)編著的(de)(de)(de)(de)《本草綱目(mu)》中,李(li)(li)時珍對(dui)救了他(ta)性命的(de)(de)(de)(de)黃(huang)芩這(zhe)味中藥推崇備加,稱之(zhi)為“藥中肯綮,如(ru)鼓應桴(fu),醫中之(zhi)妙,有如(ru)此哉(zai)!