乳(ru)腺(xian)(xian)(xian)(xian)(xian)纖(xian)(xian)維(wei)(wei)(wei)(wei)(wei)腺(xian)(xian)(xian)(xian)(xian)瘤(liu)(liu)(liu)(liu)是由(you)腺(xian)(xian)(xian)(xian)(xian)上皮和(he)纖(xian)(xian)維(wei)(wei)(wei)(wei)(wei)組織兩種成(cheng)(cheng)(cheng)(cheng)(cheng)(cheng)分混合組成(cheng)(cheng)(cheng)(cheng)(cheng)(cheng)的(de)(de)良性腫瘤(liu)(liu)(liu)(liu),好發于青年女性,與患者體(ti)內性激素水平失衡有關。對本病的(de)(de)認(ren)識還有腺(xian)(xian)(xian)(xian)(xian)纖(xian)(xian)維(wei)(wei)(wei)(wei)(wei)瘤(liu)(liu)(liu)(liu)、腺(xian)(xian)(xian)(xian)(xian)瘤(liu)(liu)(liu)(liu)之稱(cheng)(cheng),是由(you)于構成(cheng)(cheng)(cheng)(cheng)(cheng)(cheng)腫瘤(liu)(liu)(liu)(liu)的(de)(de)纖(xian)(xian)維(wei)(wei)(wei)(wei)(wei)成(cheng)(cheng)(cheng)(cheng)(cheng)(cheng)分和(he)腺(xian)(xian)(xian)(xian)(xian)上皮增(zeng)生(sheng)程度的(de)(de)不(bu)同(tong)所致。當腫瘤(liu)(liu)(liu)(liu)構成(cheng)(cheng)(cheng)(cheng)(cheng)(cheng)以腺(xian)(xian)(xian)(xian)(xian)上皮增(zeng)生(sheng)為主(zhu),而纖(xian)(xian)維(wei)(wei)(wei)(wei)(wei)成(cheng)(cheng)(cheng)(cheng)(cheng)(cheng)分較少時稱(cheng)(cheng)為纖(xian)(xian)維(wei)(wei)(wei)(wei)(wei)腺(xian)(xian)(xian)(xian)(xian)瘤(liu)(liu)(liu)(liu);若(ruo)纖(xian)(xian)維(wei)(wei)(wei)(wei)(wei)組織在腫瘤(liu)(liu)(liu)(liu)中占多數(shu),腺(xian)(xian)(xian)(xian)(xian)管成(cheng)(cheng)(cheng)(cheng)(cheng)(cheng)分較少時,稱(cheng)(cheng)為腺(xian)(xian)(xian)(xian)(xian)纖(xian)(xian)維(wei)(wei)(wei)(wei)(wei)瘤(liu)(liu)(liu)(liu);腫瘤(liu)(liu)(liu)(liu)組織由(you)大量腺(xian)(xian)(xian)(xian)(xian)管成(cheng)(cheng)(cheng)(cheng)(cheng)(cheng)分組成(cheng)(cheng)(cheng)(cheng)(cheng)(cheng)時,則(ze)稱(cheng)(cheng)為腺(xian)(xian)(xian)(xian)(xian)瘤(liu)(liu)(liu)(liu)。上述三種分類只是病理形態學方面的(de)(de)差異,其臨床(chuang)表(biao)現、治療及預(yu)后并無不(bu)同(tong),故統稱(cheng)(cheng)為纖(xian)(xian)維(wei)(wei)(wei)(wei)(wei)腺(xian)(xian)(xian)(xian)(xian)瘤(liu)(liu)(liu)(liu)。乳(ru)腺(xian)(xian)(xian)(xian)(xian)纖(xian)(xian)維(wei)(wei)(wei)(wei)(wei)腺(xian)(xian)(xian)(xian)(xian)瘤(liu)(liu)(liu)(liu)好發于乳(ru)房外上象限,呈圓形或卵圓形,臨床(chuang)多見1~3cm,生(sheng)長緩慢,妊娠或哺乳(ru)期(qi)時可急驟增(zeng)長。極少數(shu)青春期(qi)發生(sheng)的(de)(de)纖(xian)(xian)維(wei)(wei)(wei)(wei)(wei)腺(xian)(xian)(xian)(xian)(xian)瘤(liu)(liu)(liu)(liu)可在短時間內迅(xun)速增(zeng)大,直徑可達8~10cm,稱(cheng)(cheng)為巨大纖(xian)(xian)維(wei)(wei)(wei)(wei)(wei)腺(xian)(xian)(xian)(xian)(xian)瘤(liu)(liu)(liu)(liu),仍屬(shu)良性腫瘤(liu)(liu)(liu)(liu)。纖(xian)(xian)維(wei)(wei)(wei)(wei)(wei)腺(xian)(xian)(xian)(xian)(xian)瘤(liu)(liu)(liu)(liu)惡變成(cheng)(cheng)(cheng)(cheng)(cheng)(cheng)纖(xian)(xian)維(wei)(wei)(wei)(wei)(wei)肉瘤(liu)(liu)(liu)(liu)或乳(ru)腺(xian)(xian)(xian)(xian)(xian)癌者極少見,不(bu)到(dao)1%。
卵巢(chao)功能旺(wang)盛,雌激(ji)素(su)(su)水平過高,調(diao)節(jie)失(shi)衡,加之患(huan)者對雌激(ji)素(su)(su)反應敏感(gan),在雌激(ji)素(su)(su)的長(chang)期刺激(ji)下,引起乳腺(xian)腺(xian)上皮組織和纖維(wei)組織過度增生,結構紊亂(luan),形(xing)成腫瘤。由于乳腺(xian)纖維(wei)腺(xian)瘤與性(xing)激(ji)素(su)(su)分泌旺(wang)盛有關(guan),故此多發(fa)生在青年女性(xing),月經來潮(chao)前或絕經后婦女少見。
主要為乳房(fang)無(wu)(wu)痛(tong)性腫塊,很(hen)少伴(ban)有(you)乳房(fang)疼痛(tong)或(huo)乳頭溢液。腫塊往(wang)往(wang)是無(wu)(wu)意中、洗(xi)澡時,或(huo)體檢中被發現。單發腫塊居多,亦可(ke)多發,也可(ke)兩(liang)側乳房(fang)同時或(huo)先后觸(chu)及腫塊。多為圓形(xing)或(huo)橢圓形(xing),直徑常為1~3cm,亦有(you)更小或(huo)更大(da)者,偶(ou)可(ke)見巨大(da)者。境界清楚(chu),邊緣整齊,表面光滑,富有(you)彈性,無(wu)(wu)壓痛(tong),活(huo)動度較大(da),與皮膚無(wu)(wu)粘連。
1.彩超
能顯示乳房(fang)各層次結構(gou)及腫(zhong)塊形態、大小及回(hui)(hui)聲(sheng)(sheng)(sheng)狀(zhuang)況。乳腺(xian)纖維(wei)腺(xian)瘤(liu)彩超多(duo)為(wei)圓(yuan)形、卵圓(yuan)形均(jun)勻低回(hui)(hui)聲(sheng)(sheng)(sheng)腫(zhong)物,多(duo)可見(jian)光滑清晰的(de)包膜回(hui)(hui)聲(sheng)(sheng)(sheng),腫(zhong)塊后(hou)方(fang)回(hui)(hui)聲(sheng)(sheng)(sheng)正常或輕微增強,可見(jian)側方(fang)聲(sheng)(sheng)(sheng)影,腫(zhong)塊內(nei)可見(jian)伴聲(sheng)(sheng)(sheng)影的(de)粗大鈣化。彩色多(duo)普勒(le)顯示腫(zhong)塊內(nei)多(duo)無血流信號(hao)或見(jian)少(shao)量血流信號(hao),RI<0.7。
2.乳(ru)腺X線(xian)攝影
青春(chun)期(qi)女孩,致密(mi)(mi)型乳(ru)腺(xian),不(bu)適宜進(jin)行乳(ru)腺(xian)X線攝影。中年及以上婦女乳(ru)腺(xian)X線片(pian)纖維腺(xian)瘤表(biao)現(xian)為(wei)圓形、卵圓形腫塊(kuai)(kuai)(kuai)(kuai),也可呈分(fen)葉狀(zhuang),直徑多(duo)為(wei)1~3cm,邊緣(yuan)光滑清(qing)楚(chu),與等體積的正常腺(xian)體比較(jiao),腫塊(kuai)(kuai)(kuai)(kuai)呈等或(huo)稍高密(mi)(mi)度(du),周(zhou)圍可有低密(mi)(mi)度(du)暈環。部分(fen)病灶內可見鈣(gai)化(hua),鈣(gai)化(hua)多(duo)位(wei)于腫塊(kuai)(kuai)(kuai)(kuai)中心或(huo)邊緣(yuan),多(duo)呈粗(cu)顆粒(li)(li)狀(zhuang)、樹枝(zhi)狀(zhuang)或(huo)斑點(dian)狀(zhuang),也可相互融合(he)成(cheng)大塊(kuai)(kuai)(kuai)(kuai)狀(zhuang),占據腫塊(kuai)(kuai)(kuai)(kuai)大部或(huo)全部,與乳(ru)腺(xian)癌(ai)的成(cheng)簇沙粒(li)(li)樣鈣(gai)化(hua)灶不(bu)同。
3.乳腺病灶(zao)活檢
根據病史、體(ti)檢(jian)(jian)(jian)或(huo)影像(xiang)學檢(jian)(jian)(jian)查難以鑒(jian)別的(de)乳腺腫塊(kuai),可采(cai)取(qu)穿刺(ci)或(huo)手術切(qie)除的(de)方(fang)法,進(jin)行(xing)組織病理(li)學檢(jian)(jian)(jian)查,明確診斷。
乳房(fang)位于體(ti)表,典型的(de)乳腺(xian)(xian)纖維(wei)腺(xian)(xian)瘤(liu)相對容易診斷。青少(shao)年女(nv)性,無(wu)意中(zhong)或(huo)體(ti)檢(jian)(jian)中(zhong)發(fa)現乳房(fang)無(wu)痛(tong)性腫(zhong)塊(kuai)1~3cm,圓形或(huo)卵圓形,與(yu)(yu)周(zhou)圍(wei)無(wu)粘(zhan)連(lian),活動度(du)大,觸診有滑脫感;生長緩慢(man),與(yu)(yu)月經周(zhou)期(qi)無(wu)關(guan);臨(lin)床可考慮為乳腺(xian)(xian)纖維(wei)腺(xian)(xian)瘤(liu)。但對于妊娠后,特別(bie)是絕經后婦(fu)女(nv),乳房(fang)發(fa)現無(wu)痛(tong)性腫(zhong)塊(kuai),要提高(gao)警惕,不要輕易診斷乳腺(xian)(xian)纖維(wei)腺(xian)(xian)瘤(liu),應借助影像學檢(jian)(jian)查鑒別(bie)診斷,必要時需依據(ju)病理組織學檢(jian)(jian)查確診。
1.密切(qie)觀察、定期(qi)隨診
乳腺纖維腺瘤(liu)是(shi)常見的(de)良(liang)性腫瘤(liu),極少(shao)惡變。發展緩慢,沒有癥狀,不影(ying)響(xiang)生活和工作,可以密切觀察定(ding)期隨診。
2.外科手術切除
(1)觀察過程中,如(ru)乳房自查或去醫(yi)院檢查,發現(xian)纖維腺瘤有增大(da)傾向(xiang),或彩超(chao)原顯示腫塊(kuai)內無血(xue)流信號(hao)現(xian)可見大(da)量(liang)血(xue)流信號(hao),應手術(shu)切除。
(2)乳(ru)腺(xian)纖(xian)維瘤(liu)患(huan)者,準備懷孕之前,應進行(xing)纖(xian)維腺(xian)瘤(liu)切除術(shu)。原因(yin):a.乳(ru)腺(xian)纖(xian)維腺(xian)瘤(liu)的(de)發生與雌激素水平升高有關(guan),妊娠、哺(bu)乳(ru)期,隨(sui)著體內(nei)激素水平的(de)變化,可導致腫瘤(liu)體積迅速(su)增(zeng)大(da)。b.妊娠期乳(ru)腺(xian)不宜進行(xing)手(shou)術(shu)及有創(chuang)性檢查,哺(bu)乳(ru)期亦不適合手(shou)術(shu)。
(3)青少年巨大(da)纖維腺瘤(幼年性纖維腺瘤),因腫瘤生長(chang)快,體積大(da),對正常乳腺組織(zhi)產(chan)生擠壓,應考慮手(shou)術切除(chu),手(shou)術不(bu)會對以后的妊娠(shen)、哺乳產(chan)生不(bu)良影響。
(4)有乳腺(xian)癌家族史者可考慮(lv)手術切除。
3.乳腺微(wei)創(chuang)旋切手(shou)術
選擇乳(ru)腺(xian)(xian)(xian)纖(xian)維(wei)腺(xian)(xian)(xian)瘤診(zhen)斷(duan)明確者(不適宜(yi)乳(ru)腺(xian)(xian)(xian)癌的(de)治(zhi)療)。利用真空輔助旋切(qie)設(she)備,在乳(ru)腺(xian)(xian)(xian)超聲引(yin)導下(xia),一次(ci)進(jin)針多次(ci)切(qie)割將(jiang)腫瘤切(qie)除。切(qie)口僅0.3cm,恢復快(kuai),美學效(xiao)果好。纖(xian)維(wei)腺(xian)(xian)(xian)瘤完整切(qie)除后很少復發,但可再發。
建立良好地生活飲(yin)食習(xi)慣(guan),避免和減少心理緊張(zhang)因素,保持心情舒暢。控制高脂(zhi)肪、高熱量飲(yin)食的(de)攝入,不(bu)亂服用外源(yuan)性雌激(ji)素。掌握(wo)乳房(fang)自我檢查方法,養成(cheng)每(mei)月一次(ci)的(de)乳房(fang)自查習(xi)慣(guan),若(ruo)發現原因不(bu)明(ming)的(de)乳腺結節(jie),應(ying)及時去(qu)醫院診(zhen)斷。積(ji)極參加乳腺癌篩查。